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    Demand surges for Regeneron drug that Trump claims ‘cures’ Covid-19

    Doctors are reporting a spike in enquiries by patients for an experimental Covid-19 drug cocktail after Donald Trump called the Regeneron Pharmaceuticals drug “a blessing from God” that is a “cure” for the virus.Two doctors involved in the trial of the drug told Reuters that more patients are asking to participate in the drug’s trials, though medical experts have pointed out the drug, REGN-COV2, is still too early in its trial period to confirm that it can help treat Covid-19.On Wednesday, just hours after Trump praised the drug as the “cure” for the virus, Regeneron announced that it submitted an application to the Food and Drug Administration’s (FDA) for an emergency use authorization of the drug, which is a cocktail mix of two antibodies meant to aid the immune system in fighting the virus.Regeneron’s stock, and the stock of Eli Lilly, another pharmaceutical company conducting drug trials for an anti-body treatment, soared Thursday after Trump touted the treatment.“The politics of the situation would suggest to me that the story could be Trump gets Covid … then American technology fostered by the Trump administration cures Covid,” said Dr Dirk Sostman, head of research network at Houston Methodist Hospital, a trial site for Regeneron’s antibody program, who told Reuters that more patients were seeking to take part in the trial. “I would think there would be pressure on regulators [to approve the drug],” he said.Though Trump said that “hundreds of thousands” of doses were ready for use, Regeneron said that it actually has enough doses for 50,000 patients and would have enough for 300,000 patients in the coming months. The company has said 275 patients participated in the first phase of the drug trial.The US has more than 7.5m confirmed cases of Covid-19 and over 212,000 people have died of the disease, according to Johns Hopkins University.Because the drug is in clinical trials, it is only available to patients who are accepted into the trial. With approval from the FDA, drug companies can offer a treatment to patients not participating in trials under “compassionate use” rules, which are meant to make treatments accessible to patients with a life-threatening condition that has no alternative therapies available. Regeneron said that under 10 people have been given its drug under the rules.Doctors on Twitter have been voicing their concerns about promises of a cure when the treatment is still nascent.“We don’t know if it works. We don’t know about patient outcomes because it hasn’t been studied enough. Frankly, [Trump] is an anecdote,” said Dr Rob Davidson, an emergency room physician in Michigan and executive director of the Committee to Protect Medicine, in a video on Twitter.Regeneron’s drug is just the latest treatment that Trump is touting as the cure to the virus without the evidence medical experts say is necessary to actual confirm a treatment is safe and effective. In the spring, Trump infamously announced he was taking anti-malaria drug hydroxychloroquine in an attempt to prevent Covid-19, though the FDA warned against using the drug for that reason. Just a month later, the FDA revoked its emergency authorization for the drug citing growing evidence that it did not work to prevent the virus and that it had serious side effects. More

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    Pelosi questions Trump's mental state and says Congress will discuss rules for removal

    US politics

    House speaker says Democrats will consider constitution’s 25th amendment as president faces ‘disassociation from reality’

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    Nancy Pelosi suggests future discussion on Donald Trump’s fitness for office – video

    Democrats in the US Congress have announced a plan to create a commission to review whether Donald Trump is capable of carrying out his presidential duties or should face removal from office.
    The office of the House speaker, Nancy Pelosi, announced a Friday press conference about the bill after she expressed concern that Trump, who is under treatment for coronavirus at the White House, is suffering a “disassociation from reality”.
    The president has unleashed a barrage of erratic and self-contradictory tweets and declarations in recent days that have left staff scrambling and raised concerns over his stability.
    In a zigzagging interview on the Fox Business channel on Thursday, his first since being hospitalised, Trump, 74, boasted: “I’m back because I am a perfect physical specimen and I’m extremely young. And so I’m lucky in that way.”
    Pelosi, who is negotiating a Covid-19 economic stimulus plan, responded at her weekly press conference: “The plan isn’t for the president to say that he’s a perfect physical specimen. Specimen, maybe I can agree with that … And young, he said he was young.”
    Trump “is, shall we say, in an altered state right now” and “the disassociation from reality would be funny if it weren’t so deadly,” the 80-year-old speaker added while wearing a mask.
    Trump reacted angrily to Pelosi’s manoeuvre, tweeting: “Crazy Nancy is the one who should be under observation. They don’t call her Crazy for nothing!”
    He also retweeted Republican allies, including the congressman Mark Green, who posted: “I wouldn’t put it past @SpeakerPelosi to stage a coup. She has already weaponized impeachment, what’s to keep her from weaponizing the 25th amendment? We need a new Speaker!”
    In the surprise move on Thursday, Pelosi revealed that Democrats will meet to focus on the 25th amendment to the constitution, which contains a clause that allows a president to be removed from office against his will because of physical or mental incapacity.
    Her office followed up with the announcement that Pelosi and the congressman Jamie Raskin of Maryland will hold a press conference at 10.15am on Friday “to discuss the introduction of the Commission on Presidential Capacity to Discharge the Powers and Duties of Office Act”.
    The legislation will create the body and process called for in the 25th amendment to “enable Congress to help ensure effective and uninterrupted leadership in the highest office in the Executive Branch of government”, it added.
    Although the 25th amendment enables Pelosi to create such a panel to review the president’s health and fitness for office, the House of Representatives would not be able to remove Trump from office without the agreement of the vice-president, Mike Pence, and members of the cabinet. They have given no hint that such a move is imminent.
    The Democratic-led House impeached Trump last year on charges of abuse of power and obstruction of Congress after he sought to pressure Ukraine for political favours. The Republican-controlled Senate did not convict him.
    Trump tweeted last Friday morning that he had tested positive for coronavirus, and he was flown to a military hospital that evening. After a three-night stay, including a car ride to wave to his supporters, he flew back to the White House and caused outrage by removing his mask.
    He has received various treatments including doses of remdesivir, an anti-viral drug, supplemental oxygen, a controversial experimental antibody treatment by the US biotech firm Regeneron Pharmaceuticals, and dexamethasone, a steroid that some medical experts warn can cause insomnia and mood swings.
    Pelosi said: ‘I’ve quoted others to say that there are those who say that when you’re on steroids and/or if you’ve had Covid-19 or both – that there may be some impairment of judgment. But, again, that’s for the doctors and scientists to determine, but it was very strange, really surprising.”
    Trump has issued video messages and dozens of tweets that, even by the standards of his mercurial presidency, have spun in all directions and sown disarray.
    This week he abruptly announced that he was calling off the talks with Pelosi over additional coronavirus economic relief legislation, catching Republicans by surprise, only to later partly reverse his position. On Thursday he also suddenly declared that he would not take part in next week’s debate with Joe Biden, after it was announced on Thursday morning that the event would be virtual, not in-person.
    And the president has returned to the Oval Office despite isolation rules that should have kept him away and the White House itself becoming a virus hotspot. At least 20 people in or working around the executive mansion have tested positive for Covid-19 in recent days.

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    Donald Trump says he will not participate in virtual debate with Joe Biden – video
    In Trump’s hour-long interview with Fox Business on Thursday, observers found further cause for concern. He mused that he could have contracted the virus from a reception he held for military families at the White House. “They want to hug me and they want to kiss me,” he said. “And they do and, frankly, I’m not telling them to back up.”
    He claimed that his hospitalisation was unnecessary. “I didn’t have to go in, frankly; I think it would have gone away by itself.” And he made the false assertion: “I don’t think I am contagious at all. Remember this: when you catch it you get better. And then you’re immune.”
    This was after he emerged from hospital announcing that people should not fear Covid-19, despite the fact it has already killed 212,000 people in America and caused many others among the 7.6 million infected in the US to suffer serious and sometimes prolonged symptoms.
    And reacting to Wednesday’s vice-presidential debate, he called the Democratic senator Kamala Harris of California a “communist” and “monster” who wants to “open up the borders to allow killers and murderers and rapists to pour into our country”.
    Earlier on Wednesday, the president tweeted a video of himself describing his contraction of the virus as a “blessing from God”.
    Under the 25th amendment, Pence would take over if Trump were deemed unfit to serve, with Pelosi next in line. Pence reported on Thursday that he had tested negative for coronavirus.

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    Covid drug given to Trump developed using cells derived from aborted fetus

    One of the drugs taken by Donald Trump that he has touted as a potential “cure” for coronavirus was developed using human cells originally obtained from an elective abortion, a practice repeatedly denounced by the president and many of his supporters.The drug is a monoclonal antibody cocktail developed by Regeneron. The president received an 8-gram infusion under a “compassionate use” exemption when he was hospitalized over the weekend after testing positive for Covid-19. There is no cure for Covid-19, and the drug is not approved.The stem cells used to develop the drug are known as HEK-293T cells, a line of cells used in laboratories. The cells were originally derived from an embryonic kidney after an elective abortion performed in the Netherlands in the 1970s.Trump has consistently sought to restrict abortion access, including most recently, when he nominated the conservative Catholic Judge Amy Coney Barrett to the supreme court last month. The anti-abortion movement is one of Trump’s most enthusiastic bases of support.The 2020 Republican party platform explicitly opposes embryonic stem cell research, and calls for a ban on federal funding for embryonic stem cell research.Trump has already limited research using embryonic stem cells for ideological reasons. In 2019, his administration paused funding for government scientists to work on studies involving embryonic stem cells, affecting about $31m in research, according to Science Magazine.“We stopped the federal funding of fetal tissue research, which everybody felt was so important …” the president told supporters in January 2020. “We’re standing up to the pro-abortion lobby like never before.”The HEK-293T line of cells has been “immortalized”, meaning they divide freely in the lab. Regeneron said the company does not consider the cells “tissue”.“It’s how you want to parse it,” a Regeneron spokeswoman, Alexandra Bowie, told the MIT Technology Review. “But the 293T cell lines available today are not considered fetal tissue, and we did not otherwise use fetal tissue.”Development of the Regeneron antibody cocktail is supported by a $450m grant from the Biomedical Advanced Research and Development Authority (Barda).The Susan B Anthony List, a leading US anti-abortion group, did not immediately respond to a request for comment. However, the anti-abortion movement has weighed in on other Covid-19 drugs in development. At least five Covid-19 vaccine candidates used either HEK-293T cells or a proprietary line of cells developed by Janssen from a 1985 elective abortion.In April, the influential US Conference of Catholic Bishops wrote to the US government to ask that it “incentivize” vaccine candidates developed without use of such cells.“It is critically important that Americans have access to a vaccine that is produced ethically: no American should be forced to choose between being vaccinated against this potentially deadly virus and violating his or her conscience,” the letter said, as reported by Science Magazine.Regeneron has worked with the US government to develop monoclonal antibody therapies for years. In 2018, researchers from Regeneron and the US government used the same line of stem cells in development of a therapy for the Ebola virus, according to a study published in the Journal of Infectious Diseases.“Research using such stem cells allows Regeneron to model complex diseases, test new drug candidates and can help unlock new scientific insights that ultimately could lead to the discovery of new treatments for people with serious diseases,” Regeneron said in an April 2020 statement.Regeneron’s drug is not available to the public and has been tested on only 275 people to date. Therapies in the same class as Regeneron’s antibody cocktail cost on average more than $96,000 per course.The Trump administration has worked systematically to limit abortion access in the United States and abroad. Vice-President Mike Pence has said: “I long for the day Roe v Wade is sent to the ash heap of history,” referring to the US supreme court decision which has allowed for women to obtain legal abortions since 1973. More

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    Michigan governor Gretchen Whitmer slams Trump in response to kidnapping plot – video

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    Michigan governor Gretchen Whitmer called for unity and condemned Donald Trump for stoking division during the coronavirus outbreak during a press conference in which she addressed a plot to kidnap her.
    Members of two domestic terrorist groups have been charged with Whitmer’s attempted kidnap, which she said she ‘never could have imagined’ when she took office.
    Referencing the first presidential debate, when Trump told far-right group the Proud Boys to ‘stand back and standby’, the governor said he is ‘rallying’ groups such as the ones that plotted her kidnap
    Six people charged in plot to kidnap Michigan governor Gretchen Whitmer
    Trump campaign pushes debate delay as Pelosi teases discussion on his fitness for office – live

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    Donald Trump says he will not participate in virtual debate with Joe Biden – video

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    The US president made his announcement in a Fox Business interview, moments after the commission that oversees the presidential election debates said the next event would be conducted from remote locations after Trump’s Covid-19 diagnosis. The White House has refused to say when the president’s last negative test for the virus was and, as a result, it is unclear how long he has been positive. The next debate is scheduled for 15 October
    Trump says he won’t participate in virtual presidential debate with Biden – live
    Donald Trump says he will not join proposed virtual debate – full story

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    Mike Pence and Kamala Harris spar on Covid, race and climate in VP debate – video highlights

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    Mike Pence and Kamala Harris met in Utah for the only vice-presidential debate of the election, separated by Plexiglass barriers as a protection against coronavirus.
    From the pandemic to healthcare and race to the supreme court, via a fly, here are some of the key moments
    Pence-Harris vice-presidential debate: six key takeaways
    Battle for the suburbs: can Joe Biden flip Texas? – video

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