Rachael Lillis, Who Voiced Popular ‘Pokémon’ Characters, Dies at 55

Rachael Lillis, an actress who voiced the original English versions of Misty and Jessie, popular characters in the 1990s “Pokémon” anime television series, and later in the franchise’s movies and games as well, died on Saturday in Los Angeles. She was 55.

The cause was breast cancer, according to Laurie Orr, one of her sisters. Ms. Lillis had been diagnosed earlier this year.

Ms. Lillis started voice acting in the 1980s, according to her IMDB page, but her big break came in the late 1990s when she was cast in the English version of the “Pokémon” TV series, a popular Japanese anime based on the “Pokémon” video games. In hundreds of episodes over eight years, Ms. Lillis voiced the characters Misty, a trusted friend of the main character, Ash Ketchum, and Jessie, one of the show’s villains.

She also voiced those characters in “Pokemon” movies as the cultural phenomenon grew.

Ms. Lillis, who lived in Los Angeles, also was the voice of Jigglypuff, whose fairy song put listeners to sleep and was one of the creatures the characters pursue.

Ms. Lillis, who had dozens of other voice credits to her name, had a strong sense of humor and a talent for voice acting, said Eric Stuart, who voiced James, the other member of Team Rocket in the “Pokémon” series, and worked with Ms. Lillis for many years.

“If you met her, you’d not say this was so natural for her,” Mr. Stuart said in a phone interview. “Rachael in real life was pretty low key, kind of quiet and sweet,” Mr. Stuart added. “The minute she stepped in that booth it was like this whole other energy came out.”