The US military killed a leader of the Islamic State on Tuesday in an airstrike in Syria, Joe Biden said.

Maher al-Agal, identified by the Pentagon as one of the top five Islamic State leaders and the leader of the Islamic State in Syria, was killed in a drone strike in Jindayris in north-west Syria.

“His death in Syria takes a key terrorist off the field and significantly degrades the ability of [the Islamic State] to plan, resource, and conduct their operations in the region,” the president said. “It sends a powerful message to all terrorists who threaten our homeland and our interests around the world. The United States will be relentless in its efforts to bring you to justice.”

US Central Command said in a news release that an unidentified senior official in the Islamic State was also seriously injured in the strike that killed Agal.

The Pentagon said an “initial review” indicated there were no civilian casualties, though it wasn’t possible to immediately confirm that information.

Agal was “responsible for aggressively pursuing the development of Isis networks outside … Iraq and Syria”, according to US Central Command.

The Islamic State at the height of its power controlled more than 40,000 sq miles stretching from Syria to Iraq and ruled over 8 million people.

While the group’s territorial state collapsed in 2019, its leaders have turned to guerrilla tactics and been able to “efficiently restructure themselves organizationally”, according to the Washington-based Carnegie Endowment for International Peace, a nonpartisan thinktank.

The strike on Agal comes months after the leader of the Islamic State, Abu Ibrahim al-Hashimi al-Qurayshi, killed himself during a raid of his hideout by American special forces.

The Pentagon said Qurayshi blew himself up along with members of his family.