Aurelia Butler

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    F.D.A. Expands Access to Clozapine, a Key Treatment for Schizophrenia

    Federal regulators will no longer require patients to provide blood tests before receiving the drug from pharmacies.The Food and Drug Administration has taken a crucial step toward expanding access to the antipsychotic medication clozapine, the only drug approved for treatment-resistant schizophrenia, among the most devastating of mental illnesses.The agency announced on Monday that it was eliminating a requirement that patients submit blood tests before their prescriptions can be filled.Clozapine, which was approved in 1989, is regarded by many physicians as the most effective available treatment for schizophrenia, and research shows that the drug significantly reduces suicidal behavior. Clozapine is also associated with a rare side effect called neutropenia, a drop in white blood cell counts that, in its most severe form, can be life-threatening.In 2015, federal regulators imposed a regimen known as risk evaluation and mitigation strategies, or REMS, that required patients to submit to weekly, biweekly and monthly blood tests that had to be uploaded onto a database and verified by pharmacists.Physicians have long complained that, as a result, clozapine is grossly underutilized.Dr. Frederick C. Nucifora, director of the Adult Schizophrenia Clinic at the Johns Hopkins School of Medicine, said he believed that around 30 percent of patients with schizophrenia would benefit from clozapine — far more than the 4 percent who currently take it.“I have had many patients who were doing terribly, who struggled to function outside the hospital, and cycled through many medications,” he said. “If they go on clozapine, they really tend to not be hospitalized again. I’ve had people go on to finish college and work. It’s quite remarkable.”We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    Trump Administration Plans to Require Undocumented Immigrants to Register

    The move, which could expose unregistered migrants to criminal prosecution, represents a drastic escalation of the administration’s efforts to push millions of immigrants to leave on their own.The Trump administration said on Tuesday that it planned to make undocumented immigrants age 14 or older in the United States register and provide their fingerprints to the U.S. government or potentially face criminal prosecution.The announcement by the Department of Homeland Security is a drastic escalation in the Trump administration’s efforts to push millions of immigrants in the country illegally to leave on their own. Administration officials have repeatedly implored such immigrants to depart. Now they are adding an implicit threat.“President Trump and Secretary Noem have a clear message for those in our country illegally: Leave now,” Tricia McLaughlin, a spokeswoman for the department, said in a statement, referring to Homeland Security Secretary Kristi Noem. “If you leave now, you may have the opportunity to return and enjoy our freedom and live the American dream.”In a Fox News interview on Tuesday, Ms. Noem said the migrant registry plan was part of an effort to “use every single tool at our disposal to do exactly what President Trump promised the American people.”Migrants who do not register could face criminal or civil penalties, including fines. But it is unlikely the new rule will result in widespread compliance.Immigrants in the country illegally are unlikely to come forward to register with the government, especially given Mr. Trump’s threats of mass deportations. The administration also does not know where many unauthorized immigrants are, making it difficult to prosecute them if they do not register.Still, the move was a sign of the Trump administration’s intent to use every resource available to create a hostile environment for immigrants with the hope that they will leave the United States voluntarily.“We’re seeing an effort to expand arrests through any means possible, so this provision likely aims to create additional justifications to arrest and deport more individuals from the country,” said Cris Ramón, a senior immigration adviser for UnidosUS, a civil rights organization. “It also creates additional confusion for undocumented individuals, increasing the fear that’s gripped them and their families since late January.”The new plan would rely on an existing immigration law, although one that has not generally been enforced. Shortly before the United States entered World War II, the U.S. passed a law requiring undocumented immigrants to register with the U.S. government at their local post office.The department said the registration effort does not apply to those who have green cards, who are already in deportation proceedings or who entered the country with visas. But parents of undocumented immigrants younger than 14 must register their children.The requirement was set up in the flurry of Day 1 executive orders issued by the Trump administration. The current chief of staff of Immigration and Customs Enforcement, Jon Feere, has also previously advocated enforcing registration requirements. More

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    What Can House Republicans Cut Instead of Medicaid? Not Much.

    The math of the G.O.P.’s goals makes the move almost unavoidable.The House passed a budget resolution Tuesday night after the speaker, Mike Johnson, persuaded several Republican lawmakers, including those who have expressed reservations about possible Medicaid cuts, to support the bill.In theory, the budget, which kicks off the process of passing an extension of tax cuts enacted in 2017 and up to $2 trillion in spending cuts meant to partly offset them, could become law without significant cuts to Medicaid. But it won’t be easy. More

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    How the House Voted on the Budget Blueprint

    The House voted 217 to 215 to approve a budget resolution, a key step toward passing much of President Trump’s legislative agenda. All but one Republican voted “yes.” Tuesday’s vote Total 217 0 217 215 214 1 Did not vote 1 1 0 The resolution, which will also need to pass the Senate to move […] More

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    Israel Strikes Syria Hours After Country’s Leader Demands Withdrawal

    The attacks in southern Syria are part of a new policy aimed at protecting what Israel calls its “security zone” in the region. Syria’s new government has condemned that policy.The Israeli military said it had struck sites in southern Syria on Tuesday, just hours after the new Syrian leadership demanded that Israel withdraw from territory it has seized since the fall of the Assad regime.The attacks were aimed at “military targets in southern Syria, including headquarters and sites containing weapons,” the Israeli military said in a statement. It added, “The presence of military assets and forces in the southern part of Syria constitutes a threat” to Israeli citizens.Israel Katz, the Israeli defense minister, said in a statement late on Tuesday that the attacks were part of a “new policy” of ensuring a “demilitarized southern Syria.” He added that “any attempt” by either Syrian forces or militant groups to establish a presence in what Israel has deemed its “security zone” in the region “will be met with fire.”That policy was announced by Israel’s prime minister, Benjamin Netanyahu, on Sunday in a speech demanding “the complete demilitarization” of southern Syria. The speech and Israel’s actions drew the condemnation of Syria’s new government on Tuesday.The country’s interim president, Ahmed al-Shara, presided over a national unity conference on Tuesday that was intended to build consensus around the nation’s political and economic future. It concluded with a statement decrying Israeli incursions in Syria and rejecting “the provocative statements of the Israeli prime minister.”Syria’s new government said Israel was violating Syria’s sovereignty and a longstanding agreement, and called on the international community to pressure Israel “to stop the aggression.”We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    Baltimore State’s Attorney to Withdraw Motion to Vacate Adnan Syed’s Conviction

    The case of Mr. Syed, who has spent decades in prison for the murder of his high school girlfriend, was chronicled in the hit podcast “Serial.”The Baltimore City state’s attorney announced on Tuesday that his office would withdraw a motion to vacate the conviction against Adnan Syed, who has spent decades in prison while fighting charges that he had killed his high school girlfriend, Hae Min Lee.Mr. Syed’s case was chronicled in the hit podcast “Serial,” which presented new evidence and led to a swell of interest in the case. The previous Baltimore prosecutor had asked a judge to overturn the conviction in 2022, citing issues with initial evidence and other possible suspects.Though the charges against Mr. Syed were dropped that year, his conviction was later reinstated and Maryland’s highest court ordered a redo of the hearing that freed him.In a statement, the Baltimore City state’s attorney, Ivan J. Bates, said that his office had determined that the motion to vacate the conviction by his predecessor contained “falsehoods and misleading statements.”“I did not make this decision lightly, but it is necessary to preserve the credibility of our office and maintain public trust in the justice system,” Mr. Bates said.The release of “Serial” in 2014 raised doubts about the facts around the case. The podcast was downloaded more than 100 million times in its first year and brought national public attention to Mr. Syed’s case. (In 2020, The New York Times Company bought Serial Productions, the company behind the podcast.)This is a developing story. More

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    16 Are Hospitalized After Smoke Fills an Upper Manhattan Subway Station

    Investigators believe the smoke was caused by a moving train striking an object on the tracks, officials said.Sixteen people were hospitalized on Tuesday after a subway train hit an object on the tracks at an Upper Manhattan station, causing a fire that filled the station with smoke, according to fire and transit officials.A total of 18 people sustained what fire officials described as minor injuries. Two declined medical attention, officials said. The conditions of those who were hospitalized were not immediately clear Tuesday night.The episode occurred shortly before 1 p.m. at the 191st Street station at St. Nicholas Avenue in the Fort George neighborhood, officials said. The fire was brought under control within an hour, they said.Service was temporarily suspended on the No. 1 line between 145th and Dyckman Streets as a result of the fire, according to the Metropolitan Transportation Authority.By Tuesday evening, workers had replaced a rail damaged by the fire, and trains were running in both directions with delays, officials said.The 191st Street station is 173 feet, or roughly 17 stories, below St. Nicholas Avenue, making it the deepest station in New York City’s subway system. Riders enter and exit via either elevators to St. Nicholas or a 1,000-foot-long tunnel that runs to Broadway. More

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    Hundreds in Park Service Have Opted to Quit, Agency Memo Says

    More than 700 National Park Service employees have submitted resignations as part of Elon Musk’s “fork in the road” offer, according to an internal agency memo that critics of the plan said would diminish staffing ahead of the busy summer tourism season.The news of the resignations comes after a decision earlier this month at the Department of Interior to fire more than 1,000 full-time national park employees. According to the new memo sent on Tuesday and viewed by The New York Times, the additional 700 workers who agreed to the resignation plan would not be permitted to work after March 7.The staffing cuts have sparked a public outcry. Conservationists, outdoor enthusiasts and park rangers have warned that the reductions threaten to leave hundreds of national parks understaffed during the busy summer season, and already are causing some parks to reduce hours, cancel tours and close visitor centers.The national park job losses are part of a chaotic effort by President Trump to delete thousands of federal jobs. Adding to the confusion, Interior Secretary Doug Burgum has said the park service also plans to rehire thousands of workers — albeit as temporary, summer positions.“The National Park Service is hiring seasonal workers to continue enhancing the visitor experience as we embrace new opportunities for optimization and innovation in work force management,” Elizabeth Peace, a spokeswoman for the Interior Department, said in a statement.“We are focused on ensuring that every visitor has the chance to explore and connect with the incredible, iconic spaces of our national parks,” she said.Kristen Brengel, the senior vice president of government affairs at the National Parks Conservation Association, a nonprofit group, has said the temporary positions are not a substitute for the employees with years of full-time experience now lost to the park system.She also noted that about 2,000 prospective seasonal employees had their job offers rescinded when Mr. Trump, during his first days in office, imposed a hiring freeze across the government. That freeze compromised the ability to accelerate the process of rehiring those people.During the warm-weather months, as many as 325 million people visit the nation’s 63 national parks and hundreds of historic sites and other attractions managed by the park service.Federal workers received the Trump administration’s resignation offer in an email last month entitled “A Fork in the Road.” Under the offer, employees who accepted it would leave their jobs, but continue getting paid through September — and those who did not accept it risked being fired. According to the Office of Personnel Management, about 75,000 workers across the government have accepted the offer. More