Vaccines and immunisation

One of the new members of a critical federal vaccine advisory board has argued for decades that vaccines caused her son’s autism – a connection that years of large-scale studies and reviews refute.Registered nurse Vicky Pebsworth is one of eight new members to the Centers for Disease Control and Prevention’s (CDC) Advisory Committee on Immunization Practices (Acip), all hand-picked by the vaccine skeptic and Donald Trump’s health secretary Robert F Kennedy Jr.“She’s probably been anti-vax longer than RFK has,” said Dr David Gorski, a Wayne State University School of Medicine professor, who is considered an expert on the anti-vaccine movement.Kennedy fired all 17 of the committee’s previous members in June and stacked it with ideological allies. Pebsworth and Kennedy would have probably been known to each other, because their respective non-profits supported one another’s efforts.“If I had a child who I believed had been harmed by whatever – it doesn’t have to be vaccines – I wouldn’t then trust myself to be on a federal safety commission on that issue,” said Seth Mnookin, a Massachusetts Institute of Technology professor in science journalism who met and profiled Pebsworth in the mid-2000s.Pebsworth was also part of a 2020 lawsuit against Covid-19 vaccine mandates that aligns with Kennedy’s agenda. In a declaration to federal court, Pebsworth argued that “increases in the number of vaccines in the CDC schedule may be causally related to increases in the rates of chronic illness”, an assertion that appears to be based on a debunked study, but has long been a talking point of anti-vaccine activists.“They’re the oldest prominent organization,” said Mnookin, whose book is called The Panic Virus: A True Story of Medicine, Science, and Fear. The information center represents “the start of the modern-day anti-vaccine movement in the US”, said Mnookin.Pebsworth joined Acip from the National Vaccine Information Center, where she has served as volunteer research director since 2006, according to a résumé filed in the same case. The Guardian sent a list of questions and an interview request to Pebsworth, but did not receive a response.The National Vaccine Information Center started in Virginia as Dissatisfied Parents Together in 1982, before changing its name in 1995. The group went on to receive major funding support from Dr Joseph Mercola, once described as “the most influential spreader of coronavirus misinformation online”.Like other new members of Acip, Pebsworth comes to the role with medical credentials; she has a doctorate degree in nursing, taught college research courses and served as a consumer representative on federal panels.For decades, she has publicly argued that her son, Sam, was injured by the measles, mumps and rubella (MMR) vaccine in 1998 – despite evidence showing there is no connection between vaccines and autism.Pebsworth organized conferences about alternative treatments for autism as early as 2001, including one in Michigan where then-doctor Andrew Wakefield spoke and where she told a reporter she had placed her son on a restrictive diet and administered chelation therapy – a treatment for heavy metal poisoning. Neither has been found to effectively treat autism.“Back then in the early 2000s or the late 1990s, there were two main flavors of the anti-vax,” said Gorski.In Britain, Wakefield’s paper in the Lancet proposed a link between the MMR vaccine and autism. His paper would be retracted in 2010 amid evidence of fraud and conflicts of interest.“But then there was the American flavor with mercury and thimerosal, which had been used in several childhood vaccines as a preservative,” said Gorski. “Back in the day we used to call them the ‘mercury militias’, but others used to call it the ‘mercury moms’.”Thimerosal is a vaccine preservative that has been used since before the second world war. Its safety is considered settled science and yet it has been the subject of misinformation for decades.A galvanizing moment for the anti-vaccine movement came in 2015, when one of the worst measles outbreaks in years tore through Disneyland in California. The outbreak prompted lawmakers to tighten vaccine requirements for schools, drawing parents into the fray and providing a platform for anti-vaccine groups.“I used to call anti-vax the pseudoscience that spanned the political spectrum – you could find leftwing anti-vaxxers, rightwing anti-vaxxers,” said Gorski. “But now it’s really, really built into the right,” he said. “You can’t deny that any more. It’s become part of rightwing ideology.”In 2017, Pebsworth testified before a Virginia house subcommittee against a school mandate for a meningitis vaccine. In 2020, as Americans anxiously waited for a Covid-19 vaccine, she warned Americans could face unknown consequences from the vaccines. Pebsworth later testified in 2021 before the University of Hawaii’s board of regents, arguing against Covid-19 vaccines.In most public testimony, Pebsworth identifies herself not only as the volunteer research director for the National Vaccine Information Center, but also as “the mother of a child injured by his 15-month well-baby shots in 1998”.“Groups like hers and probably even more prominently the Informed Consent Action Network have seen that most vaccine policy is at the state level,” said an expert in state vaccine law who declined to go on the record for fear of retaliation from the Department of Health and Human Services.“They have a list of model legislation they encourage supporters to try to get introduced,” the expert said. At the same time, the groups have failed to accomplish their “big swings”: getting schools to drop vaccine mandates.The expert continued: “My sense is that legislators know they’re hearing from a very vocal minority. Landslide majorities still support requirements. It’s lower than it was before the pandemic, but the public still understands the needs for these laws.”By 2017, Trump was weighing whether this vocal group could become part of his coalition. Before his first inauguration in early January 2017, Trump publicly said he was considering Kennedy to head a new committee on vaccines and autism.Only days before she was appointed to ACIP, Pebsworth and the founder of the National Vaccine Information Center argued against Covid-19 vaccines, stating in part: “FDA should not be recommending mRNA Covid-19 shots for anyone until adequate scientific evidence demonstrates safety and effectiveness for both the healthy and those who are elderly or chronically ill.” More than 270 million Americans have received Covid-19 vaccines, and the federal government has closely monitored for rare events.That old trope of thimerosal played a leading role in the first meeting of Kennedy’s reconstituted Acip panel. Committee members heard a presentation against thimerosal from Lyn Redwood, the former president of the World Mercury Project, which would become Kennedy’s anti-vaccine group Children’s Health Defense. A report on thimerosal’s safety by career CDC scientists was pulled from the meeting by Kennedy’s office.Ultimately, members recommended against seasonal influenza vaccines that contain thimerosal in a decision that shocked medical and scientific communities. Pebsworth abstained, arguing she wanted to vote separately on whether to recommend influenza vaccines.Pebsworth later said she wanted to vote separately on whether to recommend seasonal flu vaccines. She did not respond to questions from the Guardian about how she would have voted on flu shots, if she had the chance. More

Robert F Kennedy Jr, the US health secretary, named eight new vaccine advisers this week to a critical Centers for Disease Control and Prevention (CDC) panel after firing all 17 experts who had held the roles.New members of the panel include experts who complained about being sidelined, a high-profile figure who has spread misinformation and medical professionals who appear to have little vaccine expertise. Kennedy made the announcement on social media.“All of these individuals are committed to evidence-based medicine, gold-standard science, and common sense,” Kennedy said in his announcement. “They have each committed to demanding definitive safety and efficacy data before making any new vaccine recommendations.”Formally called the Advisory Committee on Immunization Practices (ACIP), the panel advises the CDC on how vaccines should be distributed. Those recommendations in effect determine the vaccines Americans can access. This week, Kennedy also removed the career officials typically tasked with vetting ACIP members and overseeing the advisory group, according to CBS News.Kennedy is a widely known vaccine skeptic who profited from suing vaccine manufacturers, has taken increasingly dramatic steps to upend US vaccine policy.“ACIP is widely regarded as the international gold standard for vaccine decision-making,” said Helen Chu, one of the fired advisers, at a press conference with Patty Murray, a Democratic US senator.“We cannot replace it with a process driven by one person’s beliefs. In the absence of an independent, unbiased ACIP, we can no longer trust that safe and effective vaccines will be available to us and the people around us.”Robert W MaloneArguably the most high-profile new member, Robert W Malone catapulted to stardom during the Covid-19 pandemic, appearing across rightwing media to criticize the Biden administration while describing himself as the inventor of mRNA technology.Messenger RNA technology powers the most widely used Covid-19 vaccines. While Malone was involved in very early experiments on the technology, researchers have said his role was limited.Malone’s star rose quickly after appearing on the Joe Rogan podcast in 2022, where he and Rogan were criticized for spreading misinformation. On the show, Malone promoted the idea that both ivermectin and hydroxychloroquine could be possible treatments for Covid-19, but said research on the drugs was being suppressed. Ivermectin and hydroxychloroquine have not been shown to improve outcomes from Covid-19.“Malone has a well-documented history of promoting conspiracy theories,” said Dr Jeffrey D Klausner, an epidemiologist and infectious disease expert at the University of Southern California, who recently told the New York Times he was in touch with Kennedy about his appointments.Martin KulldorffKulldorff is a former Harvard professor of biostatistics and an infectious disease epidemiologist originally from Sweden. He said in an essay for the rightwing publication City Journal that he was fired because he refused to be vaccinated in line with the school policy.Like Malone, he rose to prominence during the pandemic as a “Covid contrarian” who criticized the scientific consensus – views he said alienated him from his peers in the scientific community. He voiced his opposition to Covid-19 vaccine mandates and, in his essay, complained of being ignored by media and shadow-banned from Twitter.Kulldorff co-authored the Great Barrington Declaration, which called for limited closures instead of pandemic lockdowns before vaccines were available. The document became a touchstone for the American political right.Before the pandemic, Kulldorff studied vaccine safety and infectious disease, including co-authoring papers with members of CDC staff, such as on the Vaccine Safety Datalink. He was a member of the CDC’s Covid Vaccine Safety Working Group in 2020, but said later he was fired because he disagreed with the agency’s decision to pause Johnson & Johnson’s Covid-19 vaccine and with Covid-19 vaccine mandates. He served on the Food and Drug Administration’s (FDA) drug safety and risk management advisory committee around the same time.He has since enjoyed support from people already within the administration, including the Great Barrington Declaration co-author Dr Jay Bhattacharya, current head of the National Institutes of Health (NIH), and Dr Vinay Prasad, head of the Food and Drug Administration’s (FDA) Center for Biologics Evaluation and Research, which handles vaccines.Cody MeissnerMeissner is a professor of pediatrics at the Geisel School of Medicine at Dartmouth. He previously held advisory roles at the FDA and CDC, including ACIP from 2008-2012.In 2021, Meissner co-wrote an editorial with Dr Marty Makary, now the head of the FDA, which criticized mask mandates for children. In April, he was listed as an external adviser to ACIP on the respiratory syncytial virus (RSV) committee.Notably, Meissner is listed in a new conflicts of interest tool launched by the health department in March. Kennedy had criticized the fired ACIP members as “plagued with persistent conflicts of interest”.“He’s a card-carrying infectious disease person who knows the burden of these diseases, and he knows the risk and the benefit,” Dr Kathryn Edwards told CBS News. Edwards previously served as chair of the FDA’s vaccine advisory panel.Vicky PebsworthPebsworth is a nurse and the former consumer representative on the FDA’s vaccine advisory committee. She is also the Pacific regional director for the National Association of Catholic Nurses, according to Kennedy’s announcement.In 2020, Pebsworth spoke at the public comment portion of an FDA advisory panel meeting on Covid-19 vaccines. There, she identified herself as the volunteer research director for the National Vaccine Information Center (NVIC), “and the mother of a child injured by his 15-month well-baby shots in 1998”.The NVIC is widely viewed as an anti-vaccine advocacy organization “whose founder Barbara Lou Fisher must be considered a key figure of the anti-vaccine movement”, according to an article from 2023 on how to counter anti-vaccine misinformation.Retsef LeviLevi is a professor of operations management at the MIT Sloan School of Management who Kennedy described as an “expert in healthcare analytics, risk management and vaccine safety”.In 2021, he opposed Covid-19 booster shot approval during the public comment portion of an FDA advisory committee hearing. In 2022, he wrote an article calling for EMS calls to be incorporated into vaccine safety data, arguing that cardiovascular side-effects could be undercounted – an article that later required correction. The potential effects of Covid-19 vaccines on heart health have been a focal point of right-leaning criticism.Last month, Levi was criticized for publishing a pre-print paper – a paper without peer review – that he co-authored with Dr Joseph Ladapo, the Florida surgeon general, a vaccine skeptic. The paper alleged that people who took the Pfizer Covid-19 vaccine were more likely to die than those who received the Moderna vaccine.Michael A RossKennedy described Ross as “a Clinical Professor of Obstetrics and Gynecology at George Washington University and Virginia Commonwealth University, with a career spanning clinical medicine, research, and public health policy”.However, as first reported by CBS News, Ross’s name does not appear in faculty directories for either school. A spokesperson for George Washington University told the outlet that Ross did work as a clinical professor, but “has not held a faculty appointment … since 2017”.A spokesperson for Virginia Commonwealth University described Ross as “an affiliate faculty member” at a regional hospital system in the Capitol region.He is also listed as a partner at Havencrest Capital Management, as a board member of “multiple private healthcare companies”.Joseph R HibbelnHibbeln is a California-based psychiatrist who previously served as acting chief for the section of nutritional neurosciences at the NIH. He describes himself as an expert on omega-3, a fatty acid found in seafood.He also serves on the advisory council of a non-profit that advocates for Americans to eat more seafood. He practices at Barton Health, a hospital system in Lake Tahoe, California. His work influenced US public health guidelines on fish consumption during pregnancy.Dr James PaganoPagano is an emergency medicine physician from Los Angeles “with over 40 years of clinical experience”, and a “strong advocate for evidence-based medicine”, according to Kennedy. More