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    Trump Administration Ends Program Critical to Search for an H.I.V. Vaccine

    The termination is the latest in a series of cuts to H.I.V. research and programs to prevent the disease.The Trump administration has dealt a sharp blow to work on H.I.V. vaccines, terminating a $258 million program whose work was instrumental to the search for a vaccine.Officials from the H.I.V. division of the National Institutes of Health delivered the news on Friday to the program’s two leaders, at Duke University and the Scripps Research Institute.Both teams were collaborating with numerous other research partners. The work was broadly applicable to a wide range of treatments for other illnesses, from Covid drugs to snake antivenom and therapies for autoimmune diseases.“The consortia for H.I.V./AIDS vaccine development and immunology was reviewed by N.I.H. leadership, which does not support it moving forward,” said a senior official at the agency who was not authorized to speak on the matter and asked not to be identified.“N.I.H. expects to be shifting its focus toward using currently available approaches to eliminate H.I.V./AIDS,” the official said.The program’s elimination is the latest in a series of cuts to H.I.V.-related initiatives, and to prevention of the disease in particular. Separately, the N.I.H. also paused funding for a clinical trial of an H.I.V. vaccine made by Moderna.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    5 Places to Turn for Accurate Health Information

    Changes to federal health websites have raised concerns about their reliability. These independent sources offer an alternative.Soon after President Donald J. Trump took office for his second term, thousands of health websites run by the federal government that kept the public informed about infectious diseases, mental health, vaccines and more were taken offline.Many eventually returned — in large part because a judge ordered the Centers for Disease Control and Prevention to temporarily restore the pages — but some had been altered, with sections on topics such as health equity and teen pregnancy deleted. The changes, along with uncertainty around the future of these sites, has led some public health experts to question whether the websites can still be trusted as the gold standard of trustworthy health information, as they’ve long been regarded.Federal health agencies are already facing a crisis of confidence. When a recent national poll asked respondents how much trust they had in the C.D.C. to make the right health recommendations, more than one-third replied “not much” or “not at all.” Nearly half said the same about the Food and Drug Administration.Experts fear that with less trust in public health institutions, more people seeking medical information might turn to social media, where misinformation is rampant. That has made it all the more valuable for the public to find evidenced-based sources of health information.Here are five websites run by independent organizations that have accurate, easy-to-understand information.1. Vaccine Education CenterOf all the health information on federal websites, medical experts have been increasingly concerned about the availability of accurate vaccine information. Robert F. Kennedy Jr., the nation’s health secretary, has been a longtime critic of vaccines and has spread misinformation about their safety for years.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    They Caught the Flu, and Never Came Home

    The virus leads to an estimated 36,000 deaths in the United States each season — many of them so sudden that families are left reeling.Lauren Caggiano had felt sick for days by the time she tested positive for the flu in an emergency room on a February afternoon. Hours later, she was in the intensive care unit. By 4 in the morning, she was on a ventilator.Ms. Caggiano, a paralegal who lived in Oceanside, Calif., doted on her two dogs and had recently become a grandmother, died two days later. She was 49.“You don’t really think, if you’re in decent health, that’s going to be what gets you,” her son, Brandon Salgado, said.Many people recover from a bout of flu within a few days or a week. But every year, the virus still kills more than 36,000 people across the United States and sends hundreds of thousands to the hospital. The Centers for Disease Control and Prevention has said that this flu season has been especially severe.Some of those who died were at greater risk for getting seriously ill because of underlying conditions or their age. Others, like Ms. Caggiano, were otherwise healthy before their infections. Some had not received the flu shot, which reduces but does not eliminate the risk of death. Some were hospitalized for weeks; others felt ill for only days before they died.All of their deaths came as a shock to the people who knew them.A Swift DeclinePart of what stunned Mr. Salgado was just how quickly his mother died.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    How Much Vaccination Stops a Measles Outbreak?

    <!–> [!–> <!–> –><!–> [–><!–> –><!–> [–><!–>Just how many? To let you discover for yourself, we simulated an outbreak of a hypothetical disease, about as contagious as the flu. (A lot less contagious than measles.)–><!–> –><!–> [–><!–>We’d like you to contain it. But first, some basics:–><!–> –><!–> [!–> <!–> –><!–>Here’s a sick person in a […] More

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    A Second Child Dies of Measles in Texas

    It is the second confirmed measles death in the U.S. in a decade. If the outbreak continues at the current pace, the nation may lose its “elimination” status.The measles crisis in West Texas has claimed the life of another child, the second death in an outbreak that has burned through the region and infected dozens of residents in bordering states.The 8-year-old girl died early Thursday morning of “measles pulmonary failure” at a hospital in Lubbock, Texas, according to records obtained by The New York Times. It is the second confirmed measles death in a decade in the United States.The first was an unvaccinated child who died in West Texas in February. Another unvaccinated person died in New Mexico after testing positive for measles, though officials have not yet confirmed that measles was the cause of death.A Trump administration official said on Saturday night that the girl’s cause of death is “still being looked at.” Since late January, when the outbreak began, West Texas has reported 480 cases of measles and 56 hospitalizations. The outbreak has also spread to bordering states, sickening 54 people in New Mexico and 10 in Oklahoma.If the virus continues to spread at this pace, the country risks losing its measles elimination status, a hard-fought victory earned in 2000. Public health officials in West Texas have predicted the outbreak will continue for a year.Robert F. Kennedy, the nation’s health secretary, has faced intense criticism for his handling of the outbreak. A prominent vaccine skeptic, he has offered muted support for vaccination and has emphasized untested treatments for measles, like cod liver oil.According to doctors in Texas, Mr. Kennedy’s endorsement of alternative treatments has contributed to patients delaying critical care and ingesting toxic levels of vitamin A.Experts also fear that the Trump administration’s recent decisions to dismantle international public health safeguards and pull funding from local health departments have made large, multistate outbreaks more likely.Measles is one of the most contagious pathogens. The virus can linger in the air for up to two hours after an infected person has left the room and spreads when a sick person breathes, coughs or sneezes.Within a week or two of being exposed, those who are infected may develop a high fever, cough, runny nose and red, watery eyes. Within a few days, a telltale rash breaks out as flat, red spots on the face and then spreads down the neck and torso to the rest of the body.In most cases, these symptoms resolve in a few weeks. But in rare cases, the virus causes pneumonia, making it difficult for patients, but especially children, to get oxygen into their lungs.It may also cause brain swelling, which can leave lasting problems, like blindness, deafness and intellectual disabilities.For every 1,000 children who get measles, one or two will die, according to the Centers for Disease Control and Prevention. The virus also harms the body’s immune defenses, leaving it vulnerable to other pathogens.Christina Jewett More

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    Trump Administration Demands Additional Cuts at C.D.C.

    In addition to reductions at agency personnel, federal regulators are demanding $2.9 billion in contract cancellations, The Times has learned.Alongside extensive reductions to the staff of the Centers for Disease Control and Prevention, the Trump administration has asked the agency to cut $2.9 billion of its spending on contracts, according to three federal officials with knowledge of the matter.The administration’s cost-cutting program, called the Department of Government Efficiency, asked the public health agency to sever roughly 35 percent of its spending on contracts about two weeks ago. The C.D.C. was told to comply by April 18, according to the officials.The cuts promise to further hamstring an agency already reeling from the loss of 2,400 employees, nearly one-fifth of its work force. On Tuesday, the administration fired C.D.C. scientists focused on environmental health and asthma, injuries, violence prevention, lead poisoning, smoking and climate change.Officials at the White House and the Department of Health and Human Services did not immediately respond to requests for comment.Abruptly cutting 35 percent of contracts would be tough for any organization or business, said Tom Inglesby, director of the Johns Hopkins Center for Health Security at the Bloomberg School of Public Health, who advised the Biden administration during Covid.“Sure, any manager can find small savings and improvements, but these kinds of demands are of the size and speed that break down organizations,” he said. “This is not the way to do good for the public or for the public’s health.”The C.D.C.’s largest contract, about $7 billion per year, goes to the Vaccines for Children Program, which purchases vaccines for parents who may not be able to afford them. That program is mandated by law and will not be affected by the cuts, according to one senior official who spoke on condition of anonymity.But other C.D.C. contracts include spending on computers and other technology, security guards, cleaning services and facilities management. The agency also hires people to build and maintain data systems and for specific research projects. Over the past several years, contracts have also supported activities related to Covid-19, one official said.Separately, H.H.S. last week abruptly discontinued C.D.C. grants of about $11.4 billion to states that were using the funds to track infectious diseases and to support mental health services, addiction treatment and other urgent health issues.At least some of the contracts D.O.G.E. is now asking the agency to discontinue may no longer be implemented because the people overseeing them have been fired. This is not the first time D.O.G.E. asked the agency to cut funding. It previously asked the C.D.C. to cut grants to Columbia University and University of Pennsylvania, saying those institutions had failed to take action against antisemitism on campus. “Funding grants and contracts are the mechanism by which we get things done,” said one C.D.C. scientist who asked to remain anonymous because of a fear of retaliation. “They are cutting off our arms and legs.” More

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    Shingles Vaccine Can Decrease Risk of Dementia, Study Finds

    A growing body of research suggests that preventing the viral infection can help stave off cognitive decline.Getting vaccinated against shingles can reduce the risk of developing dementia, a large new study finds.The results provide some of the strongest evidence yet that some viral infections can have effects on brain function years later and that preventing them can help stave off cognitive decline.The study, published on Wednesday in the journal Nature, found that people who received the shingles vaccine were 20 percent less likely to develop dementia in the seven years afterward than those who were not vaccinated.“If you’re reducing the risk of dementia by 20 percent, that’s quite important in a public health context, given that we don’t really have much else at the moment that slows down the onset of dementia,” said Dr. Paul Harrison, a professor of psychiatry at Oxford. Dr. Harrison was not involved in the new study, but has done other research indicating that shingles vaccines lower dementia risk.Whether the protection can last beyond seven years can only be determined with further research. But with few currently effective treatments or preventions, Dr. Harrison said, shingles vaccines appear to have “some of the strongest potential protective effects against dementia that we know of that are potentially usable in practice.”Shingles cases stem from the virus that causes childhood chickenpox, varicella-zoster, which typically remains dormant in nerve cells for decades. As people age and their immune systems weaken, the virus can reactivate and cause shingles, with symptoms like burning, tingling, painful blisters and numbness. The nerve pain can become chronic and disabling.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    How Covid Changed the Lives of These 29 Americans

    Five years ago, Covid took hold and the world transformed almost overnight. As routines and rituals evaporated, often replaced by grief, fear and isolation, many of us wondered: When will things go back to normal? Could they ever? Today, for many, the coronavirus pandemic seems far away and foggy, while for others it’s as visceral […] More