DNA (Deoxyribonucleic Acid)

Subterms

    More stories

    • 175 Shares169 Views

      in Elections

      Killer of 2 Women in National Park in 1996 Has Been Identified, F.B.I. Says

      by

      A convicted serial rapist who died in an Ohio prison in 2018 was responsible for the murder of a couple at Shenandoah National Park in a case that initially was believed to be a hate crime.It took the authorities one week to find the bodies of Julianne Williams and Laura Winans near their campsite at a national park in Virginia in 1996 after their family reported them missing. But it would take nearly three decades for the authorities to identify the person they believe killed them.The F.B.I. office in Richmond on Thursday announced that new DNA evidence showed that Walter Leo Jackson Sr., a convicted serial rapist from Ohio who died in prison six years ago, had killed the couple in what initially was believed to have been an anti-gay hate crime and led to charges against another man that were eventually dropped by prosecutors in 2004.“After 28 years, we are now able to say who committed the brutal murders of Lollie Winans and Julie Williams in Shenandoah National Park,” Christopher R. Kavanaugh, the U.S. attorney for the western district of Virginia, said in a news release. “I want to again extend my condolences to the Winans and Williams families and hope today’s announcement provides some small measure of solace.”An F.B.I. investigative team revisited the case in 2021, the agency said. It re-examined previous leads and interviews and evidence recovered from the site of the killings. Investigators submitted some of the evidence for DNA testing and found a match to Mr. Jackson’s DNA, the agency said.“Even though we had this DNA match, we took additional steps and compared evidence from Lollie and Julie’s murders directly to a buccal swab containing Jackson’s DNA,” Stanley M. Meador, the F.B.I. special agent in charge in Richmond, said in a news release.Mr. Jackson, who painted homes for a living, died in an Ohio prison in March 2018, officials said. He had an extensive criminal history, including convictions for rape, kidnapping and assault.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

    • 88 Shares169 Views

      in Elections

      Ancient Maya Genomes Sequenced for First Time

      by

      Thousand-year-old DNA from Chichén Itzá offers eye-opening details of the religious rituals of ancient Maya.In the spring of 1967, workers building a small airport behind Chichén Itzá, the ancient Maya city in Mexico, ran into a problem: Their excavations had uncovered human remains in the pathway of the proposed runway. The airport was set to serve V.I.P.s who wanted to visit Chichén Itzá. But with the remains so close to a major archaeological site, the work had to be halted until the bones could be examined.Any hope for a quick resolution dissolved when archaeologists who were called to the scene uncovered a chultún — an underground rainwater-storage container that, in Maya mythology, was viewed as an entrance to the subterranean land of the dead. Connected to the cistern was a cave containing more than 100 sets of human remains, almost all belonging to children. In a push to finish the airport, researchers were given just two months to excavate and exhume the cache of bones.Nearly 60 years later, ancient DNA extracted from 64 of the children is offering new insights into the religious rituals of the ancient Maya and their ties to modern descendants. In a paper published on Wednesday in the journal Nature, an international cohort of researchers revealed that the children — sacrificial victims killed between 500 and 900 A.D. — were all local Maya boys that may have been specifically selected to be killed in sibling pairs.“These are the first ancient Maya genomes to be published,” said Johannes Krause, an archaeogeneticist at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany. The DNA work provided a previously unseen glimpse into the identities of the sacrificed children. “One feels quite moved by such a finding,” Dr. Krause said, noting that he himself has a young son.The search into the genome of the Maya boys did not start as an exercise in ancient Maya rituals. In the mid-2000s, Rodrigo Barquera — now an immunogeneticist at the Max Planck Institute — was hoping to discover the genetic legacy of Mesoamerica’s deadliest pandemic.In 1545, an outbreak of Salmonella enterica spread like wildfire across what is now Mexico. Over the next century, the disease killed up to 90 percent of the Indigenous population. Pandemics like these often leave their mark on the immune genes of survivors. To uncover this genetic legacy, Dr. Barquera and his colleagues needed to compare the DNA from the precolonial remains with that of people who were born after the calamity.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

    • 163 Shares129 Views

      in Elections

      Rex Heuermann, Gilgo Beach Serial Killing Suspect, Is Charged With 2 More Murders

      by

      Rex Heuermann, who has been accused of killing four women, has been charged with the murders of two more.Rex Heuermann, who was arrested last summer and has been accused of murdering four women in the Gilgo Beach serial killings on Long Island, was indicted Thursday on murder charges in the deaths of two more women.Mr. Heuermann, 60, who has pleaded not guilty to all charges in connection with the first four women’s deaths, has remained in jail for nearly a year awaiting trial. In the meantime, investigators turned to the six other victims — four women, a man and a toddler — whose remains, like those of the first four women, were found along Ocean Parkway by Gilgo Beach.On Thursday, Mr. Heuermann was charged with killing one of them: Jessica Taylor, whose partial remains were found near Gilgo Beach in 2011 and then linked to other partial remains found eight years earlier in a remote wooded area in Manorville, a 45-minute drive east.He was also charged with killing Sandra Costilla, a 28-year-old New York woman whose remains were found in 1993 in the Hamptons. Her long unsolved murder had not previously been associated with the Gilgo Beach investigation.The new indictment followed a recent flurry of activity in the investigation: a nine-day canine search completed last month in Manorville and a wooded area in Southampton where Ms. Costilla’s body was found. Last month, investigators also conducted a six-day search of Mr. Heuermann’s home in Massapequa Park, which had been exhaustively searched for two weeks last summer after his arrest.The Gilgo investigation dates back to late 2010, when investigators discovered the first of 10 victims left along a desolate stretch of Ocean Parkway running east from Jones Beach.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

    • 113 Shares189 Views

      in Elections

      Google Unveils A.I. for Predicting Behavior of Human Molecules

      by

      The system, AlphaFold3, could accelerate efforts to understand the human body and fight disease.Artificial intelligence is giving machines the power to generate videos, write computer code and even carry on a conversation.It is also accelerating efforts to understand the human body and fight disease.On Wednesday, Google DeepMind, the tech giant’s central artificial intelligence lab, and Isomorphic Labs, a sister company, unveiled a more powerful version of AlphaFold, an artificial intelligence technology that helps scientists understand the behavior of the microscopic mechanisms that drive the cells in the human body.An early version of AlphaFold, released in 2020, solved a puzzle that had bedeviled scientists for more than 50 years. It was called “the protein folding problem.”Proteins are the microscopic molecules that drive the behavior of all living things. These molecules begin as strings of chemical compounds before twisting and folding into three-dimensional shapes that define how they interact with other microscopic mechanisms in the body.Biologists spent years or even decades trying to pinpoint the shape of individual proteins. Then AlphaFold came along. When a scientist fed this technology a string of amino acids that make up a protein, it could predict the three-dimensional shape within minutes.When DeepMind publicly released AlphaFold a year later, biologists began using it to accelerate drug discovery. Researchers at the University of California, San Francisco, used the technology as they worked to understand the coronavirus and prepare for similar pandemics. Others used it as they struggled to find remedies for malaria and Parkinson’s disease.The hope is that this kind of technology will significantly streamline the creation of new drugs and vaccines.A segment of a video from Google DeepMind demonstrating the new AlphaFold3 technology.Video by Google Deepmind“It tells us a lot more about how the machines of the cell interact,” said John Jumper, a Google DeepMind researcher. “It tells us how this should work and what happens when we get sick.”The new version of AlphaFold — AlphaFold3 — extends the technology beyond protein folding. In addition to predicting the shapes of proteins, it can predict the behavior of other microscopic biological mechanisms, including DNA, where the body stores genetic information, and RNA, which transfers information from DNA to proteins.“Biology is a dynamic system. You need to understand the interactions between different molecules and structures,” said Demis Hassabis, Google DeepMind’s chief executive and the founder of Isomorphic Labs, which Google also owns. “This is a step in that direction.”Demis Hassabis, Google DeepMind’s chief executive and the founder of Isomorphic Labs.Taylor Hill/Getty ImagesThe company is offering a website where scientists can use AlphaFold3. Other labs, most notably one at the University of Washington, offer similar technology. In a paper released on Tuesday in the scientific journal Nature, Dr. Jumper and his fellow researchers show that it achieves a level of accuracy well beyond the state of the art.The technology could “save months of experimental work and enable research that was previously impossible,” said Deniz Kavi, a co-founder and the chief executive of Tamarind Bio, a start-up that builds technology for accelerating drug discovery. “This represents tremendous promise.” More

    • 150 Shares119 Views

      in Elections

      What Makes Tiny ‘Water Bears’ So Tough? They Quickly Fix Broken DNA.

      by

      New research finds that microscopic tardigrades are remarkably good at repairing their DNA after a huge blast of radiation.To introduce her children to the hidden marvels of the animal kingdom a few years ago, Anne De Cian stepped into her garden in Paris. Dr. De Cian, a molecular biologist, gathered bits of moss, then came back inside to soak them in water and place them under a microscope. Her children gazed into the eyepiece at strange, eight-legged creatures clambering over the moss.“They were impressed,” Dr. De Cian said.But she was not finished with the tiny beasts, known as tardigrades. She brought them to her laboratory at the French National Museum of Natural History, where she and her colleagues hit them with gamma rays. The blasts were hundreds of times greater than the radiation required to kill a human being. Yet the tardigrades survived, going on with their lives as if nothing had happened.Scientists have long known that tardigrades are freakishly resistant to radiation, but only now are Dr. De Cian and other researchers uncovering the secrets of their survival. Tardigrades turn out to be masters of molecular repair, able to quickly reassemble piles of shattered DNA, according to a study published on Friday and another from earlier this year.Scientists have been trying to breach the defenses of tardigrades for centuries. In 1776, Lazzaro Spallanzani, an Italian naturalist, described how the animals could dry out completely and then be resurrected with a splash of water. In the subsequent decades, scientists found that tardigrades could withstand crushing pressure, deep freezes and even a trip to outer space.In 1963, a team of French researchers found that tardigrades could withstand massive blasts of X-rays. In more recent studies, researchers have found that some species of tardigrades can withstand a dose of radiation 1,400 times higher than what’s required to kill a person.A preflight photo of a marine tardigrade as seen magnified by 40 times under a light microscope.Boothby Lab/ReutersWe are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

    • 150 Shares149 Views

      in Elections

      Mother of Dead Baby Found at Phoenix Airport in 2005 Is Arrested

      by

      The authorities said that genetic evidence was used to find Annie Anderson of Washington State. She will be charged with first-degree murder in the death of her child, who came to be known as Baby Skylar.The dead baby girl was found in a trash bin in a women’s bathroom at main airport in Phoenix on Oct. 10, 2005. Wrapped in newspapers and a towel, the newborn had been stuffed into a plastic bag from a Marriott Hotel, the police said.Detectives immediately began investigating the death of the child, who came to be known as Baby Skylar. A medical examiner determined two days after the baby was found that she had been suffocated and was the victim of a homicide. But leads in the case eventually dried up, and the investigation remained dormant for years.On Tuesday, more than 18 years after the gruesome discovery at Terminal 4 of Phoenix Sky Harbor International Airport, the authorities announced at a news conference that they had identified and arrested the baby’s mother, Annie Anderson, 51, of Washington State, and that she would be charged with first-degree murder in the child’s death.Ms. Anderson was in custody in Washington on Tuesday, and was awaiting extradition to Maricopa County, Ariz., Lt. James Hester of the Phoenix Police Department said at the news conference.Among the few and early leads that the police had was the plastic bag in which the baby’s body had been found. That prompted detectives to investigate Marriott hotels in the Phoenix area, Lieutenant Hester said. But those leads and others proved unsuccessful.Then, in 2019, the Phoenix police partnered with the F.B.I. to use genetic genealogy, an emerging tool in solving cold cases, to look into the Baby Skylar mystery, Lieutenant Hester said.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More