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    A Mammoth DNA Discovery Helps Map an Ancient Genome in 3-D

    In 2018 an international team of scientists — from labs in Houston, Copenhagen, Barcelona and beyond — got their hands on a remarkable biological specimen: a skin sample from a 52,000-year-old woolly mammoth that had been recovered from the permafrost in Siberia. They probed the sample with an innovative experimental technique that revealed the three-dimensional architecture of the mammoth’s genome. The resulting paper was published on Thursday in the journal Cell.Hendrik Poinar, an evolutionary geneticist at McMaster University in Canada, was “floored” — the technique had successfully captured the original geometry of long stretches of DNA, a feat never before accomplished with an ancient DNA sample. “It’s absolutely beautiful,” said Dr. Poinar, who reviewed the paper for the journal.The typical method for extracting ancient DNA from fossils, Dr. Poinar said, is still “kind of cave man.” It produces short fragments of code composed of a four-letter molecular alphabet: A (adenine), G (guanine), C (cytosine), T (thymine). An organism’s full genome resides in cell nuclei, in long, unfragmented DNA strands called chromosomes. And, vitally, the genome is three-dimensional; as it dynamically folds with fractal complexity, its looping points of contact help dictate gene activity.“To have the actual architectural structure of the genome, which suggests gene expression patterns, that’s a whole other level,” Dr. Poinar said.“It’s a new kind of fossil, a fossil chromosome,” said Erez Lieberman Aiden, a team member who is an applied mathematician, a biophysicist and a geneticist and directs the Center for Genome Architecture at Baylor College of Medicine in Houston. Technically, he noted, it is a non-mineralized fossil, or subfossil, since it has not turned to stone.Erez Lieberman Aiden, director of the Center for Genome Architecture at Baylor College of Medicine in Houston.Brandon Thibodeaux for The New York TimesThe trunk of a 39,000-year-old woolly mammoth nicknamed Yuka that also yielded fossil chromosomes in the study.Love Dalén/Stockholm UniversityWe are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    A Tourist From New Mexico Is Killed by an Elephant in Zambia

    The incident came months after another tourist was killed in Zambia when an elephant charged her group. One wildlife expert said the attacks were most likely “freak accidents.”A tourist from New Mexico was killed in Zambia when an elephant charged her, according to the police commissioner who investigated the incident. She is the second tourist to be fatally attacked by an elephant in the southern African country this year.The woman who was killed, Juliana G. Letourneau, 64, of Albuquerque, had just visited Victoria Falls, a 350-foot waterfall that straddles the border between Zambia and Zimbabwe, and was heading back to her hotel on Wednesday when the group that she was traveling with encountered a herd of elephants on the road.She and others stepped out of their vehicle to observe the animals, said Auxensio Daka, the police commissioner for the southern province of Zambia, in a telephone interview on Saturday.“They stopped to watch the elephants, and unfortunately one of them charged towards them as they were standing there watching,” Mr. Daka said.Mr. Daka said that Ms. Letourneau was taken to a clinic in Mosi-oa-Tunya National Park near Livingstone, Zambia, where she was declared dead on arrival. Her injuries included deep wounds on the right shoulder blade and forehead, a fractured left ankle and a slightly depressed chest, according to a police statement.No other injuries were reported from the encounter with the elephant.Ms. Letourneau’s brother said on Saturday that he had no details about the incident, and declined to be interviewed. Other relatives could not be reached.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More