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    Gilead Agrees to Allow Generic Version of Groundbreaking H.I.V. Shot in Poor Countries

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    Many middle-income countries are left out of the deal, widening a gulf in access to critical medicines.The drugmaker Gilead Sciences on Wednesday announced a plan to allow six generic pharmaceutical companies in Asia and North Africa to make and sell at a lower price its groundbreaking drug lenacapavir, a twice-yearly injection that provides near-total protection from infection with H.I.V.Those companies will be permitted to sell the drug in 120 countries, including all the countries with the highest rates of H.I.V., which are in sub-Saharan Africa. Gilead will not charge the generic drugmakers for the licenses.Gilead says the deal, made just weeks after clinical trial results showed how well the drug works, will provide rapid and broad access to a medication that has the potential to end the decades-long H.I.V. pandemic.But the deal leaves out most middle- and high-income countries — including Brazil, Colombia, Mexico, China and Russia — that together account for about 20 percent of new H.I.V. infections. Gilead will sell its version of the drug in those countries at higher prices. The omission reflects a widening gulf in health care access that is increasingly isolating the people in the middle.Gilead charges $42,250 per patient per year for lenacapavir in the United States, where it is approved as a treatment for H.I.V. The company has said nothing about what lenacapavir will cost when used to prevent H.I.V. infections, a process called pre-exposure prophylaxis, or PrEP.The generics makers — four companies in India, one in Pakistan and one in Egypt — are expected to sell it for much less. Researchers at Liverpool University found the drug could profitably be produced for as little as $40 per patient per year, if it were being purchased in large volumes.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      W.H.O. Authorizes Mpox Vaccine, Clearing Way for Use in Africa

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      The decision is a crucial step in getting shots to the Democratic Republic of Congo, the center of the outbreak.The World Health Organization has given its authorization to a first vaccine to protect against mpox, a decision announced in such haste on Friday that it caught even the head of the company that makes the vaccine by surprise.The vaccine, made by the Danish company Bavarian Nordic, has been approved by the regulatory authorities in Europe as well as the United States and other high-income countries since a global mpox outbreak in 2022. But low- and middle-income countries rely on the W.H.O., through a process called prequalification, to determine which drugs, vaccines and health technologies are safe and efficient uses of limited health funding, and the organization had declined to act until now.The W.H.O. had come under increasing criticism for declaring a global public health emergency for mpox last month without giving a vaccine that prequalification stamp of approval, or a more provisional form of approval called emergency use authorization. Bavarian Nordic first submitted its safety and effectiveness data on the vaccine, called Jynneos, to the W.H.O. in 2023. The W.H.O. had defended its slow pace of review, saying that it needed to subject the vaccine to careful study because it, and two others that have been used to protect against mpox, were originally designed as smallpox immunizations, and because delivering it in low-resource settings such as Central Africa would involve factors different from those relating to its use in high-income countries.But on Friday morning, the W.H.O. suddenly said it was authorizing the shot.“This first prequalification of a vaccine against mpox is an important step in our fight against the disease, both in the context of the current outbreaks in Africa, and in future,” Dr. Tedros Adhanom Ghebreyesus, the W.H.O. director general, said in a statement.Paul Chaplin, Bavarian Nordic’s chief executive, said he was among the many who had been caught off guard.“We’ve got there eventually — I don’t know quite how,” he said. “But it’s good news. It’s going to make the regulatory pathway much easier.”We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      Why House Republicans Are Targeting China Weeks Before the Election

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      The G.O.P. pushed through an array of legislation to get tough on China, seeking to persuade voters that they are the party that will protect Americans from economic and military threats from Beijing.The House this week tackled a long-promised package of bills to get tough on China, but few if any have a chance of becoming law after Republicans opted to prioritize a handful of politically divisive measures that Democrats oppose.For months, House leaders had promised a bipartisan show of force against the United States’ biggest economic and military adversary, including curtailing investments in sensitive Chinese industries, clamping down on data theft and espionage, and ensuring more Chinese imports were subject to taxes and forced labor standards.But only some of those proposals made it to the floor this week. Instead, Republican leaders added a handful of partisan measures that appear to be aimed at portraying their party as stronger on countering China and Democrats, including the Biden administration, as weak.It comes weeks before the elections in which the White House and control of Congress are up for grabs.“Because the White House has chosen not to confront China and protect America’s interests, House Republicans will,” Speaker Mike Johnson, Republican of Louisiana, told reporters on Tuesday.Here’s a look at what the House did, and why.Subjecting international pandemic agreements to Senate treaty approval.Republicans, who have castigated the World Health Organization for its response to the coronavirus pandemic, pushed through a bill that would require Senate ratification of any W.H.O. agreement on pandemic preparedness. The organization is exploring ways to streamline the international response to the next pandemic.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      Dr. Anthony Fauci Recovering From West Nile Virus Infection

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      The former director of the National Institute of Allergy and Infectious Diseases had been hospitalized and was expected to make a full recovery, a spokeswoman said.Dr. Anthony Fauci, the former government scientist who was both lauded and criticized for his work on Covid-19, was recently hospitalized with a case of West Nile virus and is recovering at home, according to a spokeswoman for the doctor.“A full recovery is expected,” the spokeswoman, Jenn Kuzmuk, said in a statement on Sunday on behalf of Dr. Fauci, 83, the former director of the National Institute of Allergy and Infectious Diseases.She did not elaborate on where he was hospitalized or for how long.Dr. Jonathan LaPook, the chief medical correspondent for CBS News, shared on social media that Dr. Fauci had told him that he had fever, chills and severe fatigue and that he was hospitalized this month. Dr. Fauci said he was most likely infected by a mosquito bite that he got in his backyard, Dr. LaPook said.West Nile virus is most commonly spread through the bite of an infected mosquito and is the leading cause of mosquito-borne disease in the continental United States, according to the Centers for Disease Control and Prevention.People become infected with the virus after mosquitoes feed on infected birds and then bite people, according to the C.D.C.“People are considered dead-end hosts because, unlike birds, they do not develop high enough levels of virus in their bloodstream and cannot pass the virus on to other biting mosquitoes,” the agency says on its website.West Nile cases primarily occur during mosquito season, which starts in the summer and continues through the fall. Symptoms may include fever, headache, body aches, vomiting, diarrhea or rash.At least 216 cases of West Nile virus have been detected in 33 states this year, according to the C.D.C. There are no vaccines to prevent or medicines to treat West Nile virus in people. The best prevention against the virus is to avoid mosquito bites.Lauded as the nation’s top infectious disease expert, Dr. Fauci, President Biden’s former chief medical adviser, retired in December 2022 as director of the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, after 38 years.As the public face of American science for decades, Dr. Fauci advised seven presidents and guided the country’s response to infectious disease outbreaks from the AIDS epidemic to Covid-19.Dr. Fauci joined the faculty at Georgetown University last year as a distinguished university professor at its medical school.In June, testifying before a House panel investigating Covid’s origins, he denied Republican allegations that he had helped fund research that led to the pandemic or that he had covered up the possibility of its origins in a laboratory. More

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      Thailand Confirms First Case of New, Deadlier Mpox Strain, Clade 1b

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      The Clade Ib version of the virus had not been detected outside Africa until last week, when a case in Sweden raised concerns about a wider outbreak.Health officials in Thailand said on Thursday that they had confirmed a case of the version of mpox that prompted the World Health Organization to declare a global health emergency. It’s the second time that the new and deadlier version has been found outside Africa.The announcement of the case in Thailand is likely to stir concerns about the virus spreading more widely, especially after the version was discovered in Sweden last week. Previously the outbreak had been concentrated in the Democratic Republic of Congo.The version of the mpox virus detected in these recent cases is known as Clade Ib. Health officials are particularly concerned about it because it has a death rate of 3 percent, much higher than the 0.2 percent death rate observed in a 2022 outbreak.That earlier outbreak was driven by a version called Clade IIb, which is spread predominantly through sexual contact. Men who had sex with men proved to be the most at risk, but behavioral changes and vaccinations curbed the spread.Clade Ib appears to have spread mainly through heterosexual sex, epidemiologists have said. Another subtype, Clade Ia, has spread through household contact and exposure to affected animals in addition to sexual contact. So far, young children have been the most vulnerable to this subtype.Thai officials said on Wednesday that the infected person was a 66-year-old European man who worked in an African country with an ongoing outbreak. They did not specify which country. The man, who has a home in Thailand, was not reported to have severe symptoms.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      Michael Lewis: ‘Trump is like a psycho dad to America’

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      Interview Andrew Anthony Interview Michael Lewis: ‘Trump is like a psycho dad to America’ Andrew Anthony The uncannily prescient author of Moneyball explains how Trump’s ‘appallingly bad’ handling of the coronavirus outbreak could finally undo him Michael Lewis, author of Moneyball, The Fifth Risk and the Big Short. Photograph: Cheese Scientist/Alamy Back in December, the […] More

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      Trump's narcissism has taken a new twist. And now he has American blood on his hands | Jonathan Freedland

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      Trump’s narcissism has taken a new twist. And now he has American blood on his hands Jonathan Freedland The US president has been exposed by the coronavirus crisis. The only small comfort for the rest of the world is that he’s not their leader Donald Trump during a coronavirus briefing at the White House. Photograph: […] More

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      Coronavirus: EU states take radical steps to stem spread

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      Pandemic upends lives of millions as more countries decide to close schools Coronavirus – latest news The EU has condemned Donald Trump’s unilateral ban on travel from 26 European countries as radical efforts to contain the rapid spread of the coronavirus pandemic upended daily life for millions of people around the world. France, Ireland, Austria, […] More