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    Doctor Who Gave Matthew Perry Ketamine Will Plead Guilty, U.S. Says

    Dr. Salvador Plasencia, an urgent care clinic operator in the Los Angeles area, could face up to 40 years in prison in connection with the actor’s 2023 death.A doctor who illegally supplied the “Friends” actor Matthew Perry with the drug ketamine in the weeks leading up to Mr. Perry’s death in 2023 — traveling to his home and a parking lot to inject him — has agreed to plead guilty, according to court documents.The doctor, Salvador Plasencia, could face up to 40 years in prison and a $2 million fine on four criminal counts of distributing of ketamine, a powerful anesthetic, under the agreement, which was filed on Monday in federal court in Los Angeles.Dr. Plasencia, 43, an urgent care clinic operator in Calabasas, Calif., will become the fourth person to plead guilty in connection to Mr. Perry’s death, which the Los Angeles County medical examiner’s office determined was caused by the “acute effects” of ketamine. A court date has not been set.Mr. Perry, who publicly struggled with drinking and drug use for decades, was found floating face down in a hot tub at his Los Angeles home on Oct. 28, 2023. He was 54.An autopsy said that drowning, coronary artery disease and the effects of an opioid, buprenorphine, had contributed to his death.Ketamine, which has psychedelic properties, has emerged as increasingly popular alternative therapy for anxiety, depression, post-traumatic stress disorder and other mental health issues. It is also used recreationally.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    What to Know About the Effects of Ketamine

    Elon Musk has said that he used ketamine as a treatment in the past, but he denied reports that he was taking it frequently and recreationally.News reports detailing Elon Musk’s drug use have prompted renewed attention to ketamine, a powerful anesthetic that has become increasingly popular as a therapy for treatment-resistant depression and other mental health issues.Although Mr. Musk has acknowledged using ketamine in the past to treat depression, he has denied suggestions that he is currently using ketamine — or any other drug.“I am NOT taking drugs!” he wrote last week in a social media post following the publication of an article in The New York Times that described reports of his use of drugs on the campaign trail last year. Those drugs included ketamine and other psychedelic compounds, among them MDMA and psilocybin mushrooms.Mr. Musk left the White House last week. Since then, he and President Trump have traded barbs on social media over the president’s domestic policy bill and have mentioned government contracts with Mr. Musk’s companies and Mr. Musk’s relationship to the White House.Mr. Trump, who was briefed on the article in The Times, has been telling associates in the last day or so that Musk’s “crazy” behavior is linked to his drug use, according to a Times report citing two people with knowledge of Mr. Trump’s private conversations. But later on Friday, Mr. Trump told reporters he did not want to comment on Mr. Musk’s drug use.The very public feud between the two men has once again drawn unflattering attention to ketamine, a drug that has become increasingly available at legal clinics across the country. It is also used recreationally and can be dangerous when misused.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    5 Books on Navigating Family

    Researchers share the titles they recommend most often.When parents estranged from their children share what’s going on, many imagine other people thinking, “What’s wrong with you?” said Karl Pillemer, a professor of human development at Cornell University.Though estrangement — or family cutoff — can feel isolating, it’s actually fairly common. A 2022 YouGov poll of Americans found that 29 percent of subjects were estranged from a parent, grandparent, sibling or child.People experiencing estrangement often crave tools to deal with the loss and assurance that they aren’t alone — and a number of recent books may help make sense of what they’re going through.We asked nine experts who research the topic for recommendations. Because the field is still growing, many of them endorsed the same books. And several experts interviewed for this article appear on this list because their work was highly recommended by colleagues.The five titles below offer guidance on navigating family rifts, coping with pain and finding a path forward. But they won’t necessarily help mend broken ties.As Kathleen Smith, a therapist and faculty member at the Bowen Center for the Study of the Family in Washington, D.C., put it, “the goal is not to prevent estrangement or encourage it, but to help a person get their best thinking involved in the decision.”We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    Audio of Special Counsel Interview Adds to Renewed Debate of Biden’s Fitness as President

    A 2023 audio recording released by Axios comes on the heels of other recent disclosures that have prompted recriminations among Democrats over their handling of the matter.A 2023 audio recording of President Joseph R. Biden Jr. speaking haltingly and having memory lapses is the latest in a series of recent disclosures that have reopened a debate over Mr. Biden’s physical and mental fitness while in office and prompted fresh recriminations among Democrats.The recording, released by the news outlet Axios on Friday night, documents a four-minute portion of Mr. Biden’s interview with Robert K. Hur, a special counsel who investigated his handling of classified information.Mr. Hur had concluded early last year that “no criminal charges” were warranted in the case. But in clearing the president, Mr. Hur portrayed Mr. Biden as an “elderly man with a poor memory,” based off an hourslong interview with the president, inflaming concerns that Mr. Biden’s fitness for office had significantly declined.The audio clip did not reveal new exchanges between Mr. Hur and Mr. Biden. But it gives a fuller picture of why Mr. Hur described Mr. Biden as he did, capturing the president’s whispery voice and the long pauses in his speech. Trump administration officials plan to release the audio, according to two people familiar with the matter, speaking on the condition of anonymity to describe a decision that has yet to be announced.The audio clip comes as a forthcoming book — written by Jake Tapper of CNN and Alex Thompson of Axios — has provided new details on Mr. Biden’s mental and physical decline and chronicled how Mr. Biden’s advisers stamped out discussion of his age-related limitations. Among other issues, the book recounts Mr. Biden forgetting the names of longtime aides and allies, and outsiders who had not seen the president in some time being shocked at his appearance.Top Democrats who closed ranks to defend Mr. Biden in his moment of crisis and vouched for his fitness for office have now had to rationalize those statements. In an interview on the “Talk Easy With Sam Fragoso” podcast last month, Senator Elizabeth Warren of Massachusetts — who had urged Mr. Biden to remain in the race to the end — visibly struggled not to laugh when the host asked if the president had at the time been “as sharp as you.”We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    F.D.A. Expands Access to Clozapine, a Key Treatment for Schizophrenia

    Federal regulators will no longer require patients to provide blood tests before receiving the drug from pharmacies.The Food and Drug Administration has taken a crucial step toward expanding access to the antipsychotic medication clozapine, the only drug approved for treatment-resistant schizophrenia, among the most devastating of mental illnesses.The agency announced on Monday that it was eliminating a requirement that patients submit blood tests before their prescriptions can be filled.Clozapine, which was approved in 1989, is regarded by many physicians as the most effective available treatment for schizophrenia, and research shows that the drug significantly reduces suicidal behavior. Clozapine is also associated with a rare side effect called neutropenia, a drop in white blood cell counts that, in its most severe form, can be life-threatening.In 2015, federal regulators imposed a regimen known as risk evaluation and mitigation strategies, or REMS, that required patients to submit to weekly, biweekly and monthly blood tests that had to be uploaded onto a database and verified by pharmacists.Physicians have long complained that, as a result, clozapine is grossly underutilized.Dr. Frederick C. Nucifora, director of the Adult Schizophrenia Clinic at the Johns Hopkins School of Medicine, said he believed that around 30 percent of patients with schizophrenia would benefit from clozapine — far more than the 4 percent who currently take it.“I have had many patients who were doing terribly, who struggled to function outside the hospital, and cycled through many medications,” he said. “If they go on clozapine, they really tend to not be hospitalized again. I’ve had people go on to finish college and work. It’s quite remarkable.”We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    Former Sheriff’s Deputy Is Convicted in Killing of Colorado Man

    Andrew Buen was found guilty of criminally negligent homicide in the 2022 killing of Christian Glass, who was experiencing a mental health crisis on a mountain road.A former Colorado sheriff’s deputy who fatally shot a 22-year-old man who was experiencing a mental health crisis on a dark mountain road in 2022 was convicted Thursday of criminally negligent homicide.The former deputy, Andrew Buen, could face up to three years in prison when he is sentenced on April 14, according to the Clear Creek County District Attorney’s Office. The jury declined to convict him on the more serious charge of second-degree murder in the killing of Christian Glass, whose death prompted scrutiny of how the police handle crisis intervention, prompted changes to how officers train for similar situations and resulted in a $19 million settlement for Mr. Glass’s parents.Last year, Mr. Buen was found guilty of reckless endangerment in connection with the shooting, but the jury could not reach a verdict on the second-degree murder charge, which carries a maximum penalty of 48 years in prison. That set up this month’s trial, which lasted two weeks.Mr. Glass’s father, Simon Glass, said Thursday that conviction of Mr. Buen had brought him significant relief.“We don’t have to be constantly worrying, ‘Will he get away with it?’” Simon Glass, 56, said by phone after attending the trial. “The jury probably showed him a little more mercy than he showed our son, but it’s a conviction.”A lawyer for Mr. Buen, Mallory Revel, said in a statement that a murder count “was never the appropriate charge in this case, and we are grateful to all of the jurors for recognizing that.”We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    The Democrats Are in Disarray. Now What?

    More from our inbox:Asheville’s ChallengesMental Health Intervention Can Save Lives Gus Aronson for The New York TimesTo the Editor:Re “How Democrats Can Reinvent Themselves,” by Doug Sosnik (Opinion guest essay, Feb. 1):Mr. Sosnik claims that Democrats focused too much on “elite” special interest groups and failed to address voter frustrations about the economy and crime. He then hearkens back 30 years ago and credits President Bill Clinton’s success to his avoidance of “divisive social issues.”This glosses over reality: Mr. Clinton bowed to right-wing messaging that embraced the idea of a burdened white taxpayer and scapegoated communities of color, resulting in policies like mass incarceration and a weakened social safety net. Today, Republicans have recycled the same playbook, this time demonizing D.E.I. initiatives and “woke” activists as modern-day villains responsible for all social problems and economic woes.Mr. Sosnik’s dismissal of advocates for social justice, L.G.B.T.Q.+ rights, environmental protection and labor protections as “elite outsiders” fuels this false, harmful narrative. These groups aren’t elites, as Mr. Sosnik suggests they are. They are working people fighting to dismantle the root causes of economic insecurity and vast economic inequality — and protect our planet. The cost of silencing them will be steep.Jenice Rochelle RobinsonWashingtonTo the Editor:Please do not blame the Democrats’ situation on a failure of messaging. As any communications professional will tell you, organizations need to decide what they stand for and what their value proposition is before the experts can figure out how best broadcast them so they resonate with audiences. And it can’t just be, “We’re not that.”Democrats, there are plenty of communications and media relations experts, including me, who are distraught at what’s happening and more than willing to help you shape your messaging. But you need to figure out what you want to say before we can help you. Those conversations need to be more than just “What’s our message?”Keith BermanDenverTo the Editor:As a former senior adviser to President Bill Clinton, Doug Sosnik can perhaps be forgiven for failing to draw the solid line that leads from the Democrats’ 2024 losses straight back to Mr. Clinton’s failings more than 30 years ago — punitive criminal justice “reform,” weakening the social safety net and risky, Wall Street-favoring economic policies.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    Why Do Mental Health Conditions Lead to More Severe Covid?

    People with psychiatric conditions are more likely to be hospitalized or die of the virus. Scientists have ideas about why that might be the case.It’s been clear since the early days of the pandemic: People with mental illness are more likely to have severe outcomes from Covid. Compared to the general population, they’re at higher risk of being hospitalized, developing long Covid or dying from an infection.That fact puts mental illness on the same list as better-known Covid risk factors like cardiovascular issues, chronic kidney disease and asthma.When it comes to Covid risk, mental illness “shouldn’t be treated differently than you treat diabetes or heart disease or cancer,” said Dr. Ziyad Al-Aly, the chief of research and development at the Veterans Affairs St. Louis Healthcare System.Scientists now have a better understanding of who is vulnerable. While research has linked a wide range of mental illnesses to worse Covid outcomes, experts generally believe that the risk is greatest for people with severe or unmanaged mental health conditions — suggesting that someone with schizophrenia, for example, is more likely to get sicker from Covid than someone receiving treatment for anxiety. They also have several hypotheses about why mental illness might make people more susceptible.The Strain of StressMany mental health conditions can lead to chronically high stress levels. And stress sabotages the immune system, flooding the body with hormones like cortisol and adrenaline. Those hormones make it harder to produce certain immune cells that are crucial for fighting off illnesses.“The whole system is not designed to be constantly activated,” said Andrea Lynne Roberts, a researcher at Harvard University who has studied the effects of mental health conditions on Covid outcomes. That’s why people with mental illness may be more vulnerable to viral infections in general, from the common cold to Covid.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More