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    A Personalized Brain Pacemaker for Parkinson’s

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    When Shawn Connolly was diagnosed with Parkinson’s disease nine years ago, he was a 39-year-old daredevil on a skateboard, flipping and leaping from walls, benches and dumpsters through the streets of San Francisco. He appeared in videos and magazines, and had sponsorships from skateboard makers and shops.But gradually, he began to notice that “things weren’t really working right” with his body. He found that his right hand was cupping, and he began cradling his arm to hold it in place. His balance and alignment started to seem off.Over time, he developed a common Parkinson’s pattern, fluctuating between periods of rapid involuntary movements like “I’ve got ants in my pants” and periods of calcified slowness when, he said, “I could barely move.”A couple of years ago, Mr. Connolly volunteered for an experiment that summoned his daring and determination in a different way. He became a participant in a study exploring an innovative approach to deep brain stimulation.In the study, which was published Monday in the journal Nature Medicine, researchers transformed deep brain stimulation — an established treatment for Parkinson’s — into a personalized therapy that tailored the amount of electrical stimulation to each patient’s individual symptoms.The researchers found that for Mr. Connolly and the three other participants, the individualized approach, called adaptive deep brain stimulation, cut in half the time they experienced their most bothersome symptom.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      Heat Contributed to 47,000 Deaths in Europe Last Year, but Relief Programs Helped

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      A new study shows that behavioral and social changes can reduce heat mortality. But challenges remain as temperatures continue to rise.More than 47,000 Europeans died from heat-related causes during 2023, the world’s hottest year on record, a new report in Nature Medicine has found.But the number could have been much higher.Without adaptations to rising temperatures over the past two decades — including advances in health care, more widespread air-conditioning and improved public information that kept people indoors and hydrated during extreme temperatures — the death toll for Europeans experiencing the same temperatures at the start of the 21st century could have been 80 percent higher, according to the new study. For people over 80 years old, the death toll could have doubled.“We need to consider climate change as a health issue,” said Elisa Gallo, a postdoctoral researcher at the Barcelona Institute for Global Health, a nonprofit research center, and the lead author of the study. “We still have thousands of deaths caused by heat every year, so we still have to work a lot and we have to work faster.”Counting deaths from extreme heat is difficult, in part because death certificates don’t always reflect the role heat played in a person’s death. The study used publicly available death records in 35 countries, representing about 543 million Europeans and provided by Eurostat, the statistics office of the European Union.The researchers used an epidemiological model to analyze the deaths alongside 2023 weekly temperature records to estimate what fraction of deaths could be attributable to heat.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More