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    U.S. Study on Puberty Blockers Goes Unpublished Because of Politics, Doctor Says

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    The leader of the long-running study said that the drugs did not improve mental health in children with gender distress and that the finding might be weaponized by opponents of the care.An influential doctor and advocate of adolescent gender treatments said she had not published a long-awaited study of puberty-blocking drugs because of the charged American political environment.The doctor, Johanna Olson-Kennedy, began the study in 2015 as part of a broader, multimillion-dollar federal project on transgender youth. She and colleagues recruited 95 children from across the country and gave them puberty blockers, which stave off the permanent physical changes — like breasts or a deepening voice — that could exacerbate their gender distress, known as dysphoria.The researchers followed the children for two years to see if the treatments improved their mental health. An older Dutch study had found that puberty blockers improved well-being, results that inspired clinics around the world to regularly prescribe the medications as part of what is now called gender-affirming care.But the American trial did not find a similar trend, Dr. Olson-Kennedy said in a wide-ranging interview. Puberty blockers did not lead to mental health improvements, she said, most likely because the children were already doing well when the study began.“They’re in really good shape when they come in, and they’re in really good shape after two years,” said Dr. Olson-Kennedy, who runs the country’s largest youth gender clinic at the Children’s Hospital of Los Angeles.That conclusion seemed to contradict an earlier description of the group, in which Dr. Olson-Kennedy and her colleagues noted that one quarter of the adolescents were depressed or suicidal before treatment.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      California Passes Law Protecting Consumer Brain Data

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      The state extended its current personal privacy law to include the neural data increasingly coveted by technology companies.On Saturday, Governor Gavin Newsom of California signed a new law that aims to protect people’s brain data from being potentially misused by neurotechnology companies.A growing number of consumer technology products promise to help address cognitive issues: apps to meditate, to improve focus and to treat mental health conditions like depression. These products monitor and record brain data, which encodes virtually everything that goes on in the mind, including thoughts, feelings and intentions.The new law, which passed both the California State Assembly and the Senate with no voter opposition, amends the state’s current personal privacy law — known as the California Consumer Privacy Act — by including “neural data” under “personal sensitive information.” This includes data generated by a user’s brain activity and the meshwork of nerves that extends to the rest of the body.“I’m very excited,” said Sen. Josh Becker, Democrat of California, who sponsored the bill. “It’s important that we be up front about protecting the privacy of neural data — a very important set of data that belongs to people.”With tens of thousands of tech startups, California is a hub for tech innovation. This includes smaller companies developing brain technologies, but Big Tech companies like Meta and Apple are also developing devices that will likely involve collecting vast troves of brain data.“The importance of protecting neural data in California cannot be understated,” Sen. Becker said.The bill extends the same level of protections to neural data that it does for other data already considered sensitive under the California Consumer Privacy Act, such as facial images, DNA and fingerprints, known as biometric information.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      A ‘Life Review’ Can Be Powerful, at Any Age

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      Reflecting on the past, through writing or conversation, can help us better appreciate where we are — and where we’re going.Jodi Wellman was devastated when her mother died of a heart attack at age 58. Cleaning out her apartment made her feel even worse. Drawers and closets overflowed with abandoned projects: unpublished manuscripts and business cards for ventures that had never gotten started.“My mom was a wake-up call for me,” Ms. Wellman said. “She had these dreams that she didn’t act on.”At the time, Ms. Wellman was in her early 30s, living in Chicago and working her way up the corporate rungs at a fitness club chain. But, over the course of five years, that work began to feel empty.Determined not to stagnate like her mother, Ms. Wellman quit her job to become an executive coach, eventually entering a master’s degree program in positive psychology. There, she developed a strategy for living fully: Think about death, a lot.Now also a speaker and the author of “You Only Die Once,” Ms. Wellman, 48, believes that focusing on how short life is makes you less likely to squander it. To help her clients figure out how to spend their limited time, she asks them dozens of questions, organized by life phase — things like what activities made them happiest as a child, and what they would change about their 40s and 50s.Her approach is a twist on something called “life review,” where people systematically reflect on their past, through conversations or in writing, to identify character strengths and develop self-awareness and acceptance. The process can occur both with a partner or in small groups, and it typically unfolds in six to 10 weekly sessions.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      FDA Declines to Approve MDMA Therapy, and Seeks Further Study

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      The agency said there was insufficient data to allow the use of a treatment for PTSD that involves the drug known as Ecstasy.The Food and Drug Administration on Friday declined to approve MDMA-assisted therapy for the treatment of post-traumatic stress disorder, dealing a serious blow to the nascent field of psychedelic medicine and dashing the hopes of many Americans who are desperate for new treatments.The F.D.A. said there was insufficient data to allow its use, and it asked the company seeking approval for the treatment, Lykos Therapeutics, to conduct an additional clinical trial to assess whether the drug, commonly known as Ecstasy or molly, would be safe and effective.An additional clinical trial could add years, and millions of dollars, to the approval process.If approved, MDMA would have become the first psychedelic compound to be regulated by federal health authorities. Supporters of psychedelic medicine were deeply disappointed, and some said they were stunned, having assumed the therapy’s promising data would overcome flaws in the company’s clinical trials, which had been designed in consultation with F.D.A. scientists.“This is an earthquake for those in the field who thought F.D.A. approval would be a cinch,” said Michael Pollan, the best-selling author and co-founder of the UC Berkeley Center for the Science of Psychedelics. His book, “How to Change Your Mind,” helped catalyze public interest in the therapeutic potential of psychoactive compounds, demonized during the nation’s long war on drugs.But the agency’s decision had not been entirely unexpected, after a group of independent experts convened by the F.D.A. to evaluate Lykos’s data met in June and did not recommend the treatment. On two central questions, the experts voted overwhelmingly that the company had not proven the treatment was effective, and that the drug therapy’s benefits did not outweigh the risks.The agency generally follows the recommendations of its outside panels. Critics, however, have questioned the panel’s expertise, noting that only one of its 11 members had experience in psychedelic medicine.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      JD Vance queda bajo el foco por críticas a los ‘momentos más débiles’ de Simone Biles

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      Mientras muchos aplaudían a la campeona olímpica por haber priorizado su salud mental en 2021, el hoy candidato republicano a la vicepresidencia dijo en ese momento que los medios celebraban la debilidad.[Estamos en WhatsApp. Empieza a seguirnos ahora]El senador JD Vance, de Ohio, candidato republicano a la vicepresidencia, está siendo objeto de un nuevo escrutinio debido a declaraciones que hizo en el pasado, afirmando que la gimnasta estadounidense Simone Biles, quien el jueves ganó otra medalla de oro en los Juegos Olímpicos, había mostrado debilidad al retirarse de la edición anterior del evento por un problema de salud mental.Durante una aparición en Fox News en 2021, Vance cuestionó que Biles estuviera recibiendo elogios por haber salido de la competición en los Juegos de Tokio.“Creo que el hecho de que intentemos alabar a las personas, no por sus momentos de fortaleza, no por sus momentos de heroísmo, sino por sus momentos más débiles, hace que nuestra sociedad, digamos, terapéutica, se vea muy mal”, dijo Vance, quien en ese momento se postulaba para el Senado.Ahora que tanto Vance como Biles se encuentran de nuevo bajo los reflectores, los demócratas estaban ansiosos por destacar estos comentarios. Aida Ross, vocera del Comité Nacional Demócrata, afirmó el jueves que Vance no estaba “en posición de hablar de los ‘momentos más débiles’ de nadie”.“Mientras el resto del país celebra la actuación del equipo femenino de gimnasia de EE. UU. en los Juegos Olímpicos, JD Vance se enfrenta a su momento más débil en medio de un lanzamiento lleno de tropiezos que lo ha hecho el candidato a vicepresidente más impopular en décadas”, dijo.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      How to Exercise to Improve Your Mood

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      Physical activity can brighten your outlook and calm your nerves — if you do it strategically.We’ve all encountered that person who comes back from the gym or a run seemingly high on life. In fact, scientists say that even a single bout of exercise can alter your neurochemistry in ways that create feelings of hope, calm, connection and a generally better mood.But for others, a workout just leaves them feeling worn out.“It’s normal not to find exercise rewarding,” said Daniel Lieberman, an evolutionary biologist at Harvard University. “There’s nothing wrong with you.”While some people are simply more genetically or psychologically inclined to enjoy exercise, recent discoveries have helped experts understand why it can be such a high. And, they say, by making a few changes to your workout, you can train your body and mind to find exercise more pleasurable.It’s not just about endorphins.Scientists once thought the rush people felt from exercise came exclusively from endorphins, which act like natural opioids in the brain by relieving pain. But in recent decades, researchers have discovered a more complex cocktail of other key “feel-good” chemicals produced during movement.Each ingredient plays a distinct but complementary role, said Julia Basso, an assistant professor at Virginia Tech who runs a lab studying the effects of exercise on the brain. “These neurochemicals are really working in tandem,” she said.The most potent players appear to be endocannabinoids, which share similar molecular structure with THC, and bind to the same receptors in the brain — giving you that buzzy feeling that all is right in the world.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      Moving In Childhood Contributes to Depression, Study Finds

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      A study of more than a million Danes found that frequent moves in childhood had a bigger effect than poverty on adult mental health risk.In recent decades, mental health providers began screening for “adverse childhood experiences” — generally defined as abuse, neglect, violence, family dissolution and poverty — as risk factors for later disorders.But what if other things are just as damaging?Researchers who conducted a large study of adults in Denmark, published on Wednesday in the journal JAMA Psychiatry, found something they had not expected: Adults who moved frequently in childhood have significantly more risk of suffering from depression than their counterparts who stayed put in a community.In fact, the risk of moving frequently in childhood was significantly greater than the risk of living in a poor neighborhood, said Clive Sabel, a professor at the University of Plymouth and the paper’s lead author.“Even if you came from the most income-deprived communities, not moving — being a ‘stayer’ — was protective for your health,” said Dr. Sabel, a geographer who studies the effect of environment on disease.“I’ll flip it around by saying, even if you come from a rich neighborhood, but you moved more than once, that your chances of depression were higher than if you hadn’t moved and come from the poorest quantile neighborhoods,” he added.The study, a collaboration by Aarhus University, the University of Manchester and the University of Plymouth, included all Danes born between 1982 and 2003, more than a million people. Of those, 35,098, or around 2.3 percent, received diagnoses of depression from a psychiatric hospital.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      This Is Literally Your Brain on Drugs

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      A small new study shows reactions in the brain in people who were given psilocybin in a controlled setting.If you had to come up with a groovy visualization of the human brain on psychedelic drugs, it might look something like this.Sara Moser/Washington University School of MedicineThe image, as it happens, comes from dozens of brain scans produced by researchers at Washington University School of Medicine in St. Louis who gave psilocybin, the compound in “magic mushrooms,” to participants in a study before sending them into a functional M.R.I. scanner.The kaleidoscopic whirl of colors they recorded is essentially a heat map of brain changes, with the red, orange and yellow hues reflecting a significant departure from normal activity patterns. The blues and greens reflect normal brain activity that occurs in the so-called functional networks, the neural communication pathways that connect different regions of the brain.The scans, published Wednesday in the journal Nature, offer a rare glimpse into the wild neural storm associated with mind-altering drugs. Researchers say they could provide a potential road map for understanding how psychedelic compounds like psilocybin, LSD and MDMA can lead to lasting relief from depression, anxiety and other mental health disorders.“Psilocybin, in contrast to any other drug we’ve tested, has this massive effect on the whole brain that was pretty unexpected,” said Dr. Nico Dosenbach, a professor of neurology at Washington University and a senior author of the study. “It was quite shocking when we saw the effect size.”We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      The Reason People Aren’t Telling Joe Biden the Truth

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      They entered with courage and exited as cowards. In the past two weeks, several leaders have told me they arrived at meetings with President Biden planning to have serious discussions about whether he should withdraw from the 2024 election. They all chickened out.I don’t know whether Mr. Biden should drop out of the race. It’s impossible to predict the outcome with certainty. My concern is about the decision process. There’s a gap between what people say behind the president’s back and what they say to his face. Instead of dissent and debate, they’re falling victim to groupthink.According to the original theory, groupthink happens when people become so cohesive and close-knit that they put harmony above honesty. Extensive evidence has debunked that idea. The root causes of silence are not social solidarity but fear and futility. People bite their tongues when they doubt that it’s safe and worthwhile to speak up. Leaders who want to make informed decisions need to make it clear they value candid input.Mr. Biden has done the opposite, declaring first that only the Lord almighty could change his mind and then saying that he’ll drop out only if polls say there’s no way for him to win. That sends a strong message: If you’re not an immortal being or a time traveler from the future, it’s pointless to share any concerns about the viability of his candidacy.The president is in a tough spot. Even conceding privately that he might consider stepping aside could crush the confidence of his advisers and risk a leak to the press. But a little humility could go a long way: “I believe I’m the best qualified to govern, but I don’t know for sure. I think I can win, but I might be wrong.” Along with inviting dissent, these acts of receptiveness might make Mr. Biden more persuasive. People put more faith in a balanced argument and a leader who wants to learn.Showing openness can raise people’s confidence, but it’s not always enough to quell their fear. In our research, Constantinos Coutifaris and I found that it helps for leaders to criticize themselves out loud. That way, instead of just claiming that they want the truth, they can show that they can handle the truth. If he hasn’t already, Mr. Biden could do that by gathering his family and advisers to watch a video of the debate with him and then kicking off a candid discussion by talking about what he thought he did wrong. Reviewing the game tape together would demonstrate that he’s willing to take an honest look in the mirror.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More