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      U.S. Study on Puberty Blockers Goes Unpublished Because of Politics, Doctor Says

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      The leader of the long-running study said that the drugs did not improve mental health in children with gender distress and that the finding might be weaponized by opponents of the care.An influential doctor and advocate of adolescent gender treatments said she had not published a long-awaited study of puberty-blocking drugs because of the charged American political environment.The doctor, Johanna Olson-Kennedy, began the study in 2015 as part of a broader, multimillion-dollar federal project on transgender youth. She and colleagues recruited 95 children from across the country and gave them puberty blockers, which stave off the permanent physical changes — like breasts or a deepening voice — that could exacerbate their gender distress, known as dysphoria.The researchers followed the children for two years to see if the treatments improved their mental health. An older Dutch study had found that puberty blockers improved well-being, results that inspired clinics around the world to regularly prescribe the medications as part of what is now called gender-affirming care.But the American trial did not find a similar trend, Dr. Olson-Kennedy said in a wide-ranging interview. Puberty blockers did not lead to mental health improvements, she said, most likely because the children were already doing well when the study began.“They’re in really good shape when they come in, and they’re in really good shape after two years,” said Dr. Olson-Kennedy, who runs the country’s largest youth gender clinic at the Children’s Hospital of Los Angeles.That conclusion seemed to contradict an earlier description of the group, in which Dr. Olson-Kennedy and her colleagues noted that one quarter of the adolescents were depressed or suicidal before treatment.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      Hairballs Shed Light on Tsavo Man-Eating Lions’ Menu

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      The Tsavo man-eaters terrorized railroad workers in British East Africa in the 19th century, but their tastes went well beyond human flesh.In British East Africa in 1898, two lions living along the Tsavo River were hungry.This was bad news for the workers building a railroad there. They would retreat to their tents at night and, come morning, some of the men would be missing, the latest victims of big cats that had a hankering for human meat.“Bones, flesh, skin and blood, they devoured all, and left not a trace behind them,” wrote Lt. Col. John Henry Patterson, a British Army officer leading the railroad project.During the nine-month reign of the Tsavo man-eaters, the lions, which like most males of the area lacked manes, devoured around 35 workers. Eventually, construction of the railroad stopped completely until Colonel Patterson shot the two cats.The lions’ bodies were initially fashioned into trophy rugs. In 1925, the Field Museum in Chicago purchased the rugs for display. The two skulls ended up in the museum’s collection.It turns out that the Tsavo lions had a taste for more than men. Using hair fragments preserved in the lions’ broken teeth, scientists discovered DNA from several species. Their findings were published Friday in the journal Current Biology, offering a snapshot of the surprisingly diverse buffet of wildlife once consumed by a top predator in what is today Kenya.In the 1990s, Thomas P. Gnoske, a collections manager at the Field Museum, got a chance to examine the Tsavo lions’ skulls. He noticed hair fragments in the cats’ cracked canine teeth. In 2001, Mr. Gnoske contributed to a paper positing that the lions had developed a preference for human prey because the cats’ teeth were damaged, and our species’ flesh was easier to chew.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      What Is Considered ‘Moderate Drinking’?

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      That depends on whom you ask, and what country you live in. Here’s what the research suggests and how to think about it.Over the past several years, there has been a rise in alcohol-related deaths and a steady wave of news about the health risks of drinking. Calls for people to drink only in moderation have become more urgent. But what, exactly, does that mean?“Tongue in cheek, people have defined it as not drinking more than your doctor,” said Tim Stockwell, a scientist at the Canadian Institute for Substance Use Research.More officially, in the United States, moderate drinking is defined as one drink or less per day for women and two drinks or less per day for men. But other countries define moderate drinking, also called low-risk drinking, differently, and recent research around alcohol’s health harms has raised questions about current guidelines.How are the guidelines set?Experts used to think that low or moderate amounts of alcohol were good for you. That assumption was based on research showing that people who drank in moderation lived longer than those who abstained or drank excessively. The longevity benefit disappeared around two drinks a day for women and three drinks a day for men, Dr. Stockwell said.But many researchers now think that those conclusions were based on data analyses that had “all kinds of methodological problems,” said Elizabeth Mayer-Davis, a professor of nutrition and medicine at the University of North Carolina, Chapel Hill.For example, one issue was that many people who abstained from alcohol did so because they had existing health problems, while people who drank moderately were more likely to have healthy lifestyle habits. It created “really what was an illusion of health benefits with low to moderate amounts of drinking,” Dr. Mayer-Davis said.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      Have We Reached Peak Human Life Span?

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      After decades of rising life expectancy, the increases appear to be slowing. A new study calls into question how long even the healthiest of populations can live.The oldest human on record, Jeanne Calment of France, lived to the age of 122. What are the odds that the rest of us get there, too?Not high, barring a transformative medical breakthrough, according to research published Monday in the journal Nature Aging.The study looked at data on life expectancy at birth collected between 1990 and 2019 from some of the places where people typically live the longest: Australia, France, Italy, Hong Kong, Japan, South Korea, Spain, Sweden and Switzerland. Data from the United States was also included, though the country’s life expectancy is lower.The researchers found that while average life expectancies increased during that time in all of the locations, the rates at which they rose slowed down. The one exception was Hong Kong, where life expectancy did not decelerate.The data suggests that after decades of life expectancy marching upward thanks to medical and technological advancements, humans could be closing in on the limits of what’s possible for average life span.“We’re basically suggesting that as long as we live now is about as long as we’re going to live,” said S. Jay Olshansky, a professor of epidemiology and biostatistics at the University of Chicago at Illinois, who led the study. He predicted maximum life expectancy will end up around 87 years — approximately 84 for men, and 90 for women — an average age that several countries are already close to achieving.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      Hurricane Helene Deaths Will Continue for Years, Study Suggests

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      Research on hundreds of tropical storms finds that mortality keeps rising for more than a decade afterward, for reasons you might not expect.Over the past week, the official death toll from Hurricane Helene has surpassed 100 as the vortex creeping inland from Florida submerged homes and swept away cars. But the full weight of lost lives will be realized only years from now — and it could number in the thousands.A paper published in the journal Nature on Wednesday lays out the hidden toll of tropical storms in the continental United States. Looking at 501 events from 1930 to 2015, researchers found that the average tropical storm resulted in an additional 7,000 to 11,000 deaths over the 15 years that followed.Overall during the study period, tropical storms killed more people than automobile crashes, infectious diseases and combat for U.S. soldiers. It’s such a big number — especially compared with the 24 direct deaths caused by hurricanes on average, according to federal statistics — that the authors spent years checking the math to make sure they were right.“The scale of these results is dramatically different from what we expected,” said Solomon Hsiang, a professor of global environmental policy at the Doerr School of Sustainability at Stanford University, who conducted the study with Rachel Young, the Ciriacy-Wantrup postdoctoral fellow at the University of California, Berkeley.The pair used a technique that has also provided a more complete understanding of “excess deaths” caused by Covid-19 and heat waves. It works by looking at typical mortality patterns and isolating anomalies that could have been caused only by the variable under study — in this case, a sizable storm.Previously, researchers examined deaths and hospitalizations after hurricanes over much shorter periods. One study published in Nature found elevated hospitalizations among older Medicaid patients in the week after a storm. Another, in The Journal of the American Medical Association, associated higher death rates with U.S. counties hit by cyclones. A study in The Lancet found that across 14 countries, cyclones led to a 6 percent bump in mortality in the ensuing two weeks.Deaths from tropical storms in the U.S. have been spiking Fatalities connected to storms that struck as many as 15 years ago – measured as the number of deaths above what would otherwise be expected – are rising faster as storms increase in frequency.

      Source: Solomon Hsiang and Rachel YoungBy The New York TimesWe are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      Will A.I. Be a Bust? A Wall Street Skeptic Rings the Alarm.

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      Jim Covello, Goldman Sachs’s head of stock research, warned that building too much of what the world doesn’t need “typically ends badly.”As Jim Covello’s car barreled up highway 101 from San Jose to San Francisco this month, he counted the billboards about artificial intelligence. The nearly 40 signs he passed, including one that promoted something called Writer Enterprise AI and another for Speech AI, were fresh evidence, he thought, of an economic bubble.“Not that long ago, they were all crypto,” Mr. Covello said of the billboards. “And now they’re all A.I.”Mr. Covello, the head of stock research at Goldman Sachs, has become Wall Street’s leading A.I. skeptic. Three months ago, he jolted markets with a research paper that challenged whether businesses would see a sufficient return on what by some estimates could be $1 trillion in A.I. spending in the coming years. He said that generative artificial intelligence, which can summarize text and write software code, makes so many mistakes that it was questionable whether it would ever reliably solve complex problems.The Goldman paper landed days after a partner at Sequoia Capital, a venture firm, raised similar questions in a blog post about A.I. Their skepticism marked a turning point for A.I.-related stocks, leading to a reassessment of Wall Street’s hottest trade.Goldman’s basket of A.I. stocks, which is managed by a separate arm of the firm and includes Nvidia, Microsoft, Apple, Alphabet, Amazon, Meta and Oracle, has declined 7 percent from its peak on July 10, as investors and business leaders debate whether A.I. can justify its staggering costs.The pause has come early in the A.I. arms race. The tech industry has a history of spending big to deliver technology transitions, as it did during the personal computer and internet revolutions. Those build outs spanned five years or more before there was a reckoning.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      Michel Siffre, 85, Dies; Descended Into Caves to Study the Human Mind

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      He was a pioneer in chronobiology, the study of how our bodies understand the passage of time.On the morning of Sept. 14, 1962, reporters and onlookers began to gather around a hole in the ground, far up in the Maritime Alps between France and Italy. A few hours later, workers rigged a rope down into the darkness; soon they pulled out a small, sturdily built man named Michel Siffre.He had been inside the cave, 375 feet down, for 63 days, with only a four-volt lamp for illumination. He wore dark goggles to limit the glare of the sun, and he had to be carried to a waiting helicopter.This was no rescue: Mr. Siffre, a geologist, was conducting an experiment on himself, to see what would happen to his sense of time if he cut himself off from the normal day-night flow of life on the surface.It turns out that a lot could happen: Time as he experienced had “telescoped,” he said. His circadian rhythm of wakefulness and sleep stretched from 24 to about 25 hours. And what felt to him like one month was in fact two on the surface.“After one or two days, you don’t remember what you have done a day or two before,” he told Cabinet, an art and culture magazine, in 2008. “The only things that change are when you wake up and when you go to bed. Besides that, it’s entirely black. It’s like one long day.”Mr. Siffre, who died on Aug. 25 in Nice, was a leading figure in the field of chronobiology, the study of how the human body understands time. Previous scientists had speculated that, contrary to the prevailing idea at the time, our internal clocks are independent of the solar cycle, even as we usually adjust to its influence. Through decades of experiments beginning with that 1962 descent, he proved it.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      There Might Be More Than One Way to Make a Planet

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      Astronomers have found evidence of a process that supports an alternative, more rapid approach to planetary formation, more top down than bottom up.When it comes to making a planet, astronomers have long subscribed to what Cassandra Hall, an astronomer at the University of Georgia’s Center for Simulational Physics, refers to as the “bottom up” approach: The gas and dust swirling around a young star slowly clumps together over millions of years, and its gravity shapes it into a rounded object.But a discovery by Dr. Hall and her colleagues, published in the journal Nature this month, suggests that the picture might be more complex.In a star system 508 light-years from Earth, the researchers found conditions that support an alternative “top down” approach to planet formation, in which the fertile material circling a young star rapidly collapses into a planet. The mechanism, known as gravitational instability, could explain the existence of mysterious, massive worlds known to follow wide orbits around relatively young stars.“There’s never been real, hard evidence of it happening before,” Dr. Hall wrote in an email. “We found it!”The cosmic matter stirring around an infant star is ripe with planet-forming potential. The matter is known as a protoplanetary disk, and its rotation is generally driven by the gravity of its host star. But if that disk gets large enough, it can be influenced by its own gravity, causing the young star system to become unstable. Regions of higher density in the disk emerge in the form of spiral arms, similar to the shape of spinning clouds in a hurricane.“The star would be like the eye of the storm,” said Jess Speedie, a graduate student at the University of Victoria in Canada who led the study under the supervision of Ruobing Dong, an astrophysicist.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More