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The E.P.A. says the new rule will prevent 4,500 premature deaths annually. Industry leaders are expected to challenge the regulation, saying it will harm the economy.The Environmental Protection Agency on Wednesday tightened limits on fine industrial particles, one of the most common and deadliest forms of air pollution, for the first time in a decade.Business groups immediately objected, saying the new regulation could raise costs and hurt manufacturing jobs across the country. Public health organizations said the pollution rules would save lives and strengthen the economy by reducing hospitalizations and lost workdays.Fine particulate matter, which can include soot, can come from factories, power plants and other industrial facilities. It can penetrate the lungs and bloodstream and has been linked to serious health effects like asthma and heart and lung disease. Long-term exposure has been associated with premature deaths.The new rule lowers the annual standard for fine particulate matter to nine micrograms per cubic meter of air, down from the current standard of 12 micrograms. Over the next two years, the E.P.A. will use air sampling to identify areas that do not meet the new standard. States would then have 18 months to develop compliance plans for those areas. By 2032, any that exceed the new standard could face penalties.“Soot pollution is one of the most dangerous forms of air pollution,” Michael S. Regan, the E.P.A. administrator, said in a call with reporters on Tuesday. “This is truly a game changer for the health and well-being of communities in our country.”Mr. Regan estimated that the rule would prevent 4,500 premature deaths every year and 290,000 lost workdays because of illness. The E.P.A. maintained that the rule also would deliver as much as $46 billion in net health benefits in the first year that the standards would be fully implemented.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More