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    First Sickle Cell Gene Therapy Patient, 12, Leaves Hospital

    After 44 days, Kendric Cromer, 12, left the hospital. While his family feels fortunate that he was the first to receive a treatment, their difficult experiences hint at what others will be up against.Kendric Cromer, 12, left Children’s National Hospital in a wheelchair on Wednesday, wearing a T-shirt and cap printed with designs from the anime series “Naruto” and a black face mask. Staff lined the hallway, cheering and waving noisemakers. He had just become the first patient to receive a gene therapy for sickle cell since it was approved — a therapy that is expected to free him from the ravages of the disease.After 44 days in the hospital, he was a bit dazed.“I thought I would have sickle cell for the rest of my life,” he said. The disease had deprived him of his childhood, making everyday activities, like playing basketball or riding a bike, impossible because they could bring on searing pain, often resulting in hospitalizations.But despite the celebratory atmosphere, Kendric and his parents are still shuddering over what they endured during his hospital stay.Nothing, absolutely nothing — not all the discussions with doctors, not all of their reading and highlighting of texts, not the 13-page consent form that included organ damage and even death as possible outcomes — prepared them for what he would go through.About 100,000 people in the United States have sickle cell disease. For the 20,000 or so with the most severe disease, gene therapy may be their only hope of living a normal life. The disease is caused by a mutation in hemoglobin genes that leads to crescent-shaped red blood cells, which tend to get stuck in blood vessels, causing episodes of excruciating pain. The blockages can damage organs, cause strokes and shorten lives.Until recently, most saw no way out.Then, last December, the Food and Drug Administration approved a $3.1 million sickle cell gene therapy by Bluebird Bio of Somerville, Mass., and a $2.2 million treatment by Vertex Pharmaceuticals of Boston. That potentially gives patients like Kendric, if their insurance will pay for the therapy, a path to a life that is not shadowed by the ravages of the disease.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    First Day of a ‘New Life’ for a Boy With Sickle Cell

    There was supposed to be a special party for Kendric Cromer, 12, last Wednesday, but it had to be postponed because he was too groggy to celebrate.It was meant to mark the first day of his new life — the day he became one of the first children ever to be treated with a newly approved gene therapy that will free him from the sickle cell disease that has stolen his childhood.On Sept. 11, despite the excitement of the moment, Kendric was unable to keep his eyes open as he lay in his hospital bed at Children’s National Hospital in Washington because of the drugs he had been given in preparation for his treatment.His life with the disease has been punctuated by episodes of excruciating pain, requiring days in the hospital as doctors tried to control it. Sickle cell eroded his hip bones. It prevented him from riding a bike or playing soccer or even going outside when the temperature was below 55 degrees Fahrenheit because cold often brought on intense pain.Now he could see a future — in a month or so — without pain from sickle cell.“I can’t wait to start my new life,” he told his mother, Deborah Cromer.His disease is caused by an inherited genetic mutation that leads to blood cells that form crescent shapes — sickles — instead of discs. Trapped in blood vessels and organs, the cells cause damage and pain. Gene therapy fixes that problem by giving the patient a new, normal hemoglobin gene.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    Three MDMA Studies Are Retracted by Scientific Journal

    The journal Psychopharmacology has retracted three papers about MDMA-assisted therapy based on what the publication said was unethical conduct at one of the study sites where the research took place.Several of the papers’ authors are affiliated with Lykos Therapeutics, the drug company whose application for MDMA-assisted therapy to treat post-traumatic stress disorder was rejected last week by the Food and Drug Administration. The company said the research in the retracted papers was not part of its application to the F.D.A. In declining to approve Lykos’s application, the agency cited concerns about missing data and problems with the way the company’s study was designed, according to a statement released by Lykos on Friday.The F.D.A. has asked Lykos to conduct an additional clinical trial of its MDMA-assisted therapy, which would have been the first psychedelic medicine to win approval by federal regulators. Lykos has said it would appeal the decision.The journal retraction was first reported by Stat, the health and medical news website.On Sunday, Lykos said that it disagreed with Psychopharmacology’s decision and that it would file an official complaint with the Committee on Publication Ethics, a nonprofit that sets guidelines for academic publications.“The articles remain scientifically sound and present important contributions to the study of potential treatments for PTSD,” the company said in the statement.The incident cited by Psychopharmacology has been well documented. In 2015, an unlicensed Canadian therapist who took part in the trial engaged in a sexual relationship with a participant after the conclusion of the trial’s dosing sessionsIn civil court documents, the patient, Meaghan Buisson, said she was sexually assaulted by the therapist, Richard Yensen, who at the time was working alongside his wife, a licensed therapist. Mr. Yensen has said the relationship was consensual and initiated by Ms. Buisson. Six months after the final session, she moved from Vancouver to Cortes Island, in British Columbia, where the couple lived, according to court documents. The relationship between patient and practitioner continued for more than a year, the documents said. Professional associations in both Canada and the United States prohibit sexual relationships between psychologists and patients for at least two years after their final session. The incident helped highlight some of the challenges associated with psychedelic medicine, which can render patients especially vulnerable during dosing sessions. For that reason, most clinical trials involving psychedelic compounds require the presence of two mental health professionals. (Lykos’s trials with MDMA require only one of the practitioners to be licensed.)The Multidisciplinary Association for Psychedelic Studies, or MAPS, is the nonprofit that carried out the research and later created Lykos to market its proprietary MDMA-assisted therapy. The association publicly acknowledged the incident in 2019, adding that it had been reported to the F.D.A. and to Canadian health authorities.The company acknowledged on Sunday that it had failed to notify Psychopharmacology about the violations, but it said that the oversight should have been addressed through a correction, not a retraction. More

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    FDA Declines to Approve MDMA Therapy, and Seeks Further Study

    The agency said there was insufficient data to allow the use of a treatment for PTSD that involves the drug known as Ecstasy.The Food and Drug Administration on Friday declined to approve MDMA-assisted therapy for the treatment of post-traumatic stress disorder, dealing a serious blow to the nascent field of psychedelic medicine and dashing the hopes of many Americans who are desperate for new treatments.The F.D.A. said there was insufficient data to allow its use, and it asked the company seeking approval for the treatment, Lykos Therapeutics, to conduct an additional clinical trial to assess whether the drug, commonly known as Ecstasy or molly, would be safe and effective.An additional clinical trial could add years, and millions of dollars, to the approval process.If approved, MDMA would have become the first psychedelic compound to be regulated by federal health authorities. Supporters of psychedelic medicine were deeply disappointed, and some said they were stunned, having assumed the therapy’s promising data would overcome flaws in the company’s clinical trials, which had been designed in consultation with F.D.A. scientists.“This is an earthquake for those in the field who thought F.D.A. approval would be a cinch,” said Michael Pollan, the best-selling author and co-founder of the UC Berkeley Center for the Science of Psychedelics. His book, “How to Change Your Mind,” helped catalyze public interest in the therapeutic potential of psychoactive compounds, demonized during the nation’s long war on drugs.But the agency’s decision had not been entirely unexpected, after a group of independent experts convened by the F.D.A. to evaluate Lykos’s data met in June and did not recommend the treatment. On two central questions, the experts voted overwhelmingly that the company had not proven the treatment was effective, and that the drug therapy’s benefits did not outweigh the risks.The agency generally follows the recommendations of its outside panels. Critics, however, have questioned the panel’s expertise, noting that only one of its 11 members had experience in psychedelic medicine.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    ‘Eldest Daughter Syndrome’ and Sibling Birth Order: Does it Matter?

    “Eldest daughter syndrome” assumes that birth order shapes who we are and how we interact. Does it?In a TikTok video that has been watched more than 6 million times, Kati Morton, a licensed marriage and family therapist in Santa Monica, Calif., lists signs that she says can be indicative of “eldest daughter syndrome.”Among them: an intense feeling of familial responsibility, people-pleasing tendencies and resentment toward your siblings and parents.On X, a viral post asks: “are u happy or are u the oldest sibling and also a girl”?Firstborn daughters are having a moment in the spotlight, at least online, with memes and think pieces offering a sense of gratification to responsible, put-upon big sisters everywhere. But even mental health professionals like Ms. Morton — herself the youngest in her family — caution against putting too much stock in the psychology of sibling birth order, and the idea that it shapes personality or long term outcomes.“People will say, ‘It means everything!’ Other people will say, ‘There’s no proof,’” she said, noting that eldest daughter syndrome (which isn’t an actual mental health diagnosis) may have as much to do with gender norms as it does with birth order. “Everybody’s seeking to understand themselves, and to feel understood. And this is just another page in that book.”What the research says about birth orderThe stereotypes are familiar to many of us: Firstborn children are reliable and high-achieving; middle children are sociable and rebellious (and overlooked); and youngest children are charming and manipulative.Studies have indeed found ties between a person’s role in the family lineup and various outcomes, including educational attainment and I.Q. (though those scores are not necessarily reliable measures of intelligence), financial risk tolerance and even participation in dangerous sports. But many studies have focused on a single point in time, cautioned Rodica Damian, a social-personality psychologist at the University of Houston. That means older siblings may have appeared more responsible or even more intelligent simply because they were more mature than their siblings, she said, adding that the sample sizes in most birth order studies have also been relatively small.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    Traumatic Brain Injury Found in Maine Gunman Could Have Wide Ramifications

    Exposure to blasts, even at low levels, may play a much greater role in veterans’ mental health struggles than has been known, with implications for treatment strategies and for criminal justice.Shredded connections deep in the brain. Battered and scarred blood vessels that are no longer able to support neurons. Clumps of dead cell debris marking a long pattern of injury.The results of the autopsy of Robert R. Card II, the Army Reservist who killed 18 people, then himself, in the deadliest shooting in Maine’s history, left little question that his brain was profoundly damaged. But the finding raises other questions that have broad implications for the military and for the nation’s millions of veterans.Mr. Card was a grenade range instructor who never deployed to combat. He is not known to have ever hit his head in a serious car crash, he never played football, and he does not appear to have had any other accidents that might account for the damage to his brain.His only exposure came from routine training blasts on the training range — at a level that is supposed to be safe.If those blasts were still strong enough to profoundly damage his brain, as it appears happened, then how many other troops are being exposed to the same risk? How many veterans may be struggling with similar injuries that have gone unseen or been misunderstood? How should those veterans be treated if they seek mental health care, or are accused of crimes?“The implications are just so large,” said Frank Larkin, a former Navy SEAL and sergeant-at-arms of the U.S. Senate, whose son, Ryan, also a Navy SEAL, died by suicide and was found to have extensive brain damage from blasts.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    Does Therapy Culture Help or Hurt Us?

    More from our inbox:Trump Pardoning Himself? An ‘Appalling Idea’Trump’s WeightImproving Access to E-BooksGraphicaArtis/Getty ImagesTo the Editor: Re “Hey, America, Grow Up!” by David Brooks (column, Aug. 11), about how an emphasis on trauma makes adults immature:As a psychiatrist, I feel that Mr. Brooks makes several valid points regarding trauma but fails ultimately to thread the needle.A good psychiatrist or therapist identifies the real trauma in a patient’s past — typically from events in childhood at the hands of parents or other family members — while simultaneously discouraging the kind of victim mind-set that displaces past pain onto present-day scapegoats.The goal is to illuminate the real trauma, which requires re-evaluating what is often an idealized remembrance of one’s upbringing, so that the patient can stop projecting malice onto anyone and instead regain a sense of agency. As the saying goes, those who forget the past are condemned to repeat it.If we fail as a culture to acknowledge the well-established long-term consequences, both physical and psychological, of legitimate trauma, we will wind up creating more people who identify as victims, not fewer.Christopher BaileyKirkland, Wash.To the Editor:One thing David Brooks’s good column leaves untouched is how much resistance to the hyperinflation of “trauma” there has been among psychotherapists themselves.In 1967, Anna Freud, Sigmund Freud’s daughter, wrote that the concept had become so “carelessly used” that its “blurring” could lead to “abandonment and loss of a valuable concept.” In 1978, psychiatrist Henry Krystal, an Auschwitz survivor and founder of contemporary trauma theory, said flatly that the use of the term “has become so loose that it has become virtually useless.”Of course, “trauma culture” has a life of its own, independent of psychiatric or psychological knowledge. And no small number of therapists have fully cashed in from Trauma, Inc., which is, indeed, big business.But my sense is that, even in the culture at large, “trauma” hype may have run its course. What follows may be greater “maturity,” as Mr. Brooks and many others would hope, or it may be just the next form of mishegoss.Henry GreenspanAnn Arbor, Mich.The writer is an emeritus psychologist at the University of Michigan.To the Editor:Wouldn’t it be nice if David Brooks’s ideas about how people should “throw off some of the tenets of the therapeutic culture” and “weave their stable selves through the commitments to and attachments with others” in order to build a culture of maturity were realistic?But try telling that to people who have grown up in poverty, who have never had adequate health insurance or medical care, who grew up in families rife with violence and abuse, who live in communities with chronic gun violence, and who have to drop out of high school to give birth to a baby.What can you weave in there? And who can you attach to when your life and the lives of those around you are a mess, and you live in a world that you have little hope of escaping?Debra KuppersmithDobbs Ferry, N.Y.The writer is a psychoanalyst.To the Editor:David Brooks made some excellent observations about our country’s growing narcissism. But he missed a key prescription for change: helping Americans develop a sense of purpose.This starts with treating challenges as temporary setbacks and harnessing our talents and efforts in the service of something bigger than ourselves. We need to lose the “me” and find the “we.”Studies show that people who feel a sense of purpose in their lives — through family, friends, work or community — are overall more resilient and report a greater sense of well-being. This message feels especially urgent for adolescent girls in America who are experiencing record levels of isolation, depression and suicidal thoughts.Until Americans commit to a purpose-driven mind-set, we will continue to wallow in our current obsession with victimization and search out cheap ways to validate our self-worth.Suzanne ChazinChappaqua, N.Y.Trump Pardoning Himself? An ‘Appalling Idea’Haiyun Jiang for The New York TimesTo the Editor: It has become commonplace to suggest that one difference between a state and a federal conviction of Donald Trump is that Mr. Trump could not pardon himself from a state conviction if he is elected president, implying that he could pardon his own federal offenses. It’s long past time to stop giving this appalling discussion of self-pardons any air.A president pardoning himself for his own crimes is the very definition of unchecked power. Revolutionaries called it tyranny, which in this context is a better word. The idea that our executive has so much power that the rule of law does not apply to him because he could forgive himself betrays what the Revolutionary War was about.The Constitution separated the powers of the government into three branches. It empowers Congress with the legislative power and the courts with the judicial power. The idea that a president could make himself immune from both other branches — in the furtherance of a crime — is inexcusable.Mr. Trump has floated this idea before and some allies are resurrecting it again. It’s born in the brevity of the Constitution’s pardon power. But it flouts both the rule of law and the separation of powers essential to the Constitution. We should be outraged.Andrew J. KennedyMonroeville, Pa.The writer is a lawyer.Trump’s WeightTo the Editor: Re “Trump Is Booked at Jail in Atlanta in Election Case” (front page, Aug. 25):Donald Trump weighs only 215 pounds? Forget the mug shot T-shirts; his campaign should be selling whatever brand of scale he’s using.Alan RutkowskiVictoria, British ColumbiaImproving Access to E-BooksAnn Johansson for The New York TimesTo the Editor: Re “What Does It Mean to Own a Book?” (Business, Aug. 13):I would like to thank David Streitfeld for his piece shining a light on the innovative and visionary work done by Brewster Kahle and the Internet Archive. In the discussion about the complexity of providing digital access, the work of our nation’s libraries and nonprofits like the Digital Public Library of America that support them should not be overlooked.Public libraries across the country offered access to over a billion digital e-books and half a billion digital audiobooks in fiscal year 2021. They circulated 460 million digital items and spent nearly $600 million to provide that access. And these numbers continue to grow.Mr. Streitfeld rightly points out that many titles are increasingly expensive for libraries to acquire, especially those from the “big five” publishers, which only offer licenses that are limited to a certain number of loans or length of time. However, the Digital Public Library of America works with hundreds of midsize and independent publishers to offer more reasonable terms including, for example, a perpetual one-user-at-a-time license that functions much like library ownership of a print book.Right now, legislators in several states are working with librarians to draft legislation that would enshrine the rights of libraries to acquire digital content on reasonable terms.Libraries need our support to ensure that as the transition into a digital world continues, access to knowledge becomes more and not less accessible.John S. BrackenChicagoThe writer is the executive director of the nonprofit Digital Public Library of America. More

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    After His Arraignment, Trump Lashes Out

    More from our inbox:‘A Great Day for Liberals’ in Wisconsin and ChicagoA Renewed Interest in Freudian PsychoanalysisLos cargos contra Trump representan la culminación de una investigación de casi cinco años de duración.Dave Sanders para The New York TimesTo the Editor:Re “Trump Charged With 34 Felonies” (front page, April 5):After Judge Juan M. Merchan warned at Donald Trump’s arraignment that all parties must refrain from making statements about the case with the potential to incite violence and civil unrest, what does the former president who can’t keep his mouth shut do during his speech a few hours later?He says hateful things about Judge Merchan and his family, and vilifies District Attorney Alvin Bragg, District Attorney Fani Willis in Georgia and the special counsel Jack Smith.And one of the former president’s sons put a photograph of Judge Merchan’s daughter on social media — a clear invitation to violence.It’s time for the former president to be gagged. And when he speaks out with hateful words again, a contempt order and jail time may put a sock in his mouth. About time.Gail ShorrWilmette, Ill.To the Editor:Crowd size has always been important to Donald Trump. It is the metric he uses, along with TV ratings, to measure his impact, to gauge his popularity, to feed his ego.The crowd that showed up Tuesday at his arraignment was hardly composed overwhelmingly of Trump supporters. It looked as if the media and anti-Trump people more than countered his base.No matter how Mr. Trump spins it, no matter how many times at his future rallies he proclaims an overwhelming showing of support in New York City, the camera doesn’t lie.It was good to see him cut down to size Tuesday. For the first time in his adult life he could not control the narrative. He called for a massive protest, he predicted “death and destruction” if he was charged, and he got neither.Len DiSesaDresher, Pa.To the Editor:The April 5 front-page headline “Even as Biden Has Oval Office, Predecessor Has the Spotlight” is a statement that is true only because your newspaper and other media outlets allow Donald Trump to occupy center stage.This behavior of the media has been mentioned many times before, and many believe that the tens of millions of dollars’ worth of free publicity provided to Mr. Trump during the 2016 campaign contributed to his winning the election.It is now 2023 and we are facing an election that could well decide the future of America. I am therefore requesting that The Times stop paying so much attention to Mr. Trump (we’ve heard everything he has to say many times before) effective immediately.David SommersKensington, Md.To the Editor:I felt a real jolt seeing the photo of former President Donald Trump seated at the table in a Manhattan courtroom. It was the jolt of the norms of American justice falling back into alignment.Christopher HermanWashington‘A Great Day for Liberals’ in Wisconsin and ChicagoJanet Protasiewicz, the liberal candidate in Wisconsin’s Supreme Court election, during her election night party in Milwaukee on Tuesday. She ran on her open support of abortion rights.Jamie Kelter Davis for The New York TimesTo the Editor:Re “Liberal Wins Wisconsin Court Race, in Victory for Abortion Rights Backers” (news article, April 5):While New York and the nation were fixated on the circus that was Donald Trump’s arraignment, a special election was held in Wisconsin that decided whether conservatives or liberals would control that state’s Supreme Court. Janet Protasiewicz, a Milwaukee County judge, won the race and gave liberals control of the highest court in Wisconsin.Wisconsin is an important swing state, and this new balance of power in the court will have dramatic effects on abortion rights, potential election interference and how election districts are drawn. Conservatives, who have had control of the Supreme Court, will no longer be able to gerrymander voting districts to favor Republicans, nor will they be able to successfully challenge the results of a free and fair election.While this is only one state, we may see similar results in other swing states like Michigan, Pennsylvania and, yes, even Texas. Donald Trump is to Democrats the gift that just keeps on giving.Henry A. LowensteinNew YorkTo the Editor:Three news stories from your newspaper indicate that Tuesday was a great day for liberals and progressives: “Trump Charged With 34 Felonies,” “Liberal Wins Wisconsin Court Race, in Victory for Abortion Rights Backers” and “Rejecting a ‘Republican in Disguise,’ Chicago Voters Elect Johnson as Next Mayor.”While conservative Republicans are obsessed with culture wars and MAGA, progressives are making political headway. Let’s hope that we continue on this march to liberalism till our nation is free from prejudices, curbs on reproductive and gender freedoms, relentless gun-related violence, etc.Michael HadjiargyrouCenterport, N.Y.A Renewed Interest in Freudian Psychoanalysis Photo Illustration by Elizabeth Renstrom for The New York TimesTo the Editor:Re “Back to the Couch With Freud” (Sunday Styles, March 26):It is true that people “see what they want in Freud.” Thus, a younger generation might think Freud “gay friendly” because a 1935 letter declared, “Homosexuality is nothing to be ashamed of, no vice, no degradation.”However, the article omits that Freud went on to describe homosexuality in that same letter as an “arrest of sexual development.”Freud’s theory that gay people suffered from psychological stunted growth rationalized many decades of discrimination in which openly gay men and women were refused psychoanalytic training because they were “developmentally arrested.” Only in 1991 did the American Psychoanalytic Association change its policies refusing admission to gay candidates.I am glad that Freud is having a renaissance. However, any reading or interpretation of his work should not ignore the historical context in which he lived and the ways, for better or worse, in which some of his theories have been used to discriminate.Jack DrescherNew YorkThe writer, a clinical professor of psychiatry at Columbia University, is the author of “Psychoanalytic Therapy and the Gay Man.”To the Editor:I was pleased to see New York Times coverage of the “Freudaissance,” which I have been a joyful participant in for more than a decade now, both personally and professionally.One of the understandings I have come to, having spent countless hours on both sides of the proverbial couch, in both psychoanalytic and cognitive behavioral contexts, is that these two approaches do not really diverge from each other as much as many tend to assume that they do.I see the C.B.T. founder Aaron Beck’s three levels of cognition (automatic thoughts, core beliefs and cognitive schemas) mapping neatly onto Freud’s topographical model of the mind (the conscious, preconscious and unconscious, respectively).And I see the dialectic behavioral therapy founder Marsha Linehan’s construct of the “wise mind” as an integration of the rational and emotional minds matching Freud’s structural model of the ego as a synthesis of superego and id.Different terms resonate differently in different generations and with different individuals, but rather than disproving or undermining Freud’s theories, I see today’s evidence-based approaches as indications that the father of modern psychology was apparently onto something more than a century ago.Rachel N. WynerWest Hempstead, N.Y.The writer is a clinical psychologist. More