Vaccination and Immunization

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      W.H.O. Authorizes Mpox Vaccine, Clearing Way for Use in Africa

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      The decision is a crucial step in getting shots to the Democratic Republic of Congo, the center of the outbreak.The World Health Organization has given its authorization to a first vaccine to protect against mpox, a decision announced in such haste on Friday that it caught even the head of the company that makes the vaccine by surprise.The vaccine, made by the Danish company Bavarian Nordic, has been approved by the regulatory authorities in Europe as well as the United States and other high-income countries since a global mpox outbreak in 2022. But low- and middle-income countries rely on the W.H.O., through a process called prequalification, to determine which drugs, vaccines and health technologies are safe and efficient uses of limited health funding, and the organization had declined to act until now.The W.H.O. had come under increasing criticism for declaring a global public health emergency for mpox last month without giving a vaccine that prequalification stamp of approval, or a more provisional form of approval called emergency use authorization. Bavarian Nordic first submitted its safety and effectiveness data on the vaccine, called Jynneos, to the W.H.O. in 2023. The W.H.O. had defended its slow pace of review, saying that it needed to subject the vaccine to careful study because it, and two others that have been used to protect against mpox, were originally designed as smallpox immunizations, and because delivering it in low-resource settings such as Central Africa would involve factors different from those relating to its use in high-income countries.But on Friday morning, the W.H.O. suddenly said it was authorizing the shot.“This first prequalification of a vaccine against mpox is an important step in our fight against the disease, both in the context of the current outbreaks in Africa, and in future,” Dr. Tedros Adhanom Ghebreyesus, the W.H.O. director general, said in a statement.Paul Chaplin, Bavarian Nordic’s chief executive, said he was among the many who had been caught off guard.“We’ve got there eventually — I don’t know quite how,” he said. “But it’s good news. It’s going to make the regulatory pathway much easier.”We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      As Polio Vaccines Arrive in Gaza, Distributing Them Is the Next Challenge

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      Polio vaccines arrived in Gaza on Monday, kicking off an expansive effort to vaccinate more than 640,000 Palestinian children and curb a potential outbreak, the United Nations, Israel and health authorities in Gaza said, after the first confirmed case of the disease in the territory in 25 years.The U.N. children’s fund, UNICEF, said it was bringing in 1.2 million doses of polio vaccine for children in Gaza in cooperation with the World Health Organization, the main U.N. agency that aids Palestinians, known as UNRWA, and other groups.The Gaza Health Ministry confirmed on Monday that the vaccines had reached Gaza and that preparations to launch the vaccination campaign for children under 10 were underway. It was not immediately clear how quickly the vaccines could be distributed to vaccination centers in Gaza, where continued hostilities and bombardment have hindered humanitarian efforts during 10 months of war.The ministry warned that inoculations alone could not be effective, amid a lack of clean water and personal hygiene supplies, and issues with sewage and waste collection in overcrowded areas where displaced families were sheltering. It said medical teams would need to spread out across the territory, “which requires an urgent cease-fire.”Children walking near garbage and raw sewage at a camp for displaced Palestinians in Deir al Balah in central Gaza this month.Eyad Baba/Agence France-Presse — Getty ImagesThe W.H.O. chief, Tedros Adhanom Ghebreyesus, said in a statement on Thursday that a 10-month-old child in Gaza had contracted polio and become paralyzed in one leg. The virus had been found last month in wastewater samples, but this was the first confirmed case in Gaza in a quarter-century.COGAT, the Israeli defense ministry’s agency that oversees policy for the Palestinian territories, said in a statement on Monday that the vaccines had been delivered to Gaza through the Kerem Shalom border crossing with Israel. The agency added that the campaign would be conducted in coordination with the Israeli military “as part of the routine humanitarian pauses” that it observes, which it said would allow Palestinians to reach vaccination centers.In June, Israel announced that it would observe partial daily suspensions of its military activity in areas of Gaza, calling them humanitarian pauses, saying they were aimed at making it safer for humanitarian groups to deliver aid in the territory. According to UNICEF, at least 95 percent of children will need to receive both doses of the vaccine to prevent the spread of the disease and reduce the risk of its re-emergence, “given the severely disrupted health, water and sanitation systems in the Gaza Strip.”UNICEF and the W.H.O. in a statement called on “all parties to the conflict” to implement a weeklong humanitarian pause in Gaza to allow “children and families to safely reach health facilities” for the doses. The statement added that “without the humanitarian pauses, the delivery of the campaign will not be possible.”Philippe Lazzarini, the director of UNRWA, said on Friday that the agency’s medical teams would distribute the vaccines at its clinics and through its mobile health teams. He added that “delaying a humanitarian pause will increase the risk of spread among children.”Rawan Sheikh Ahmad More

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      Leonard Hayflick, Who Discovered Why No One Lives Forever, Dies at 96

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      A biomedical researcher, he found that normal cells can divide only a certain number of times before they age — which, he said, explained aging on a cellular level.Leonard Hayflick, a biomedical researcher who discovered that normal cells can divide only a certain number of times — setting a limit on the human life span and frustrating would-be-immortalists everywhere — died on Aug. 1 at his home in Sea Ranch, Calif. He was 96.His son, Joel Hayflick, said the cause was pancreatic cancer.Like many great scientific findings, Dr. Hayflick’s came somewhat by accident. As a young scientist in the early 1960s at the Wistar Institute, a research organization at the University of Pennsylvania, he was trying to develop healthy embryonic cell lines in order to study whether viruses can cause certain types of cancer.He and a colleague, Paul Moorhead, soon noticed that somatic — that is, nonreproductive — cells went through a phase of division, splitting between 40 and 60 times, before lapsing into what he called senescence.As senescent cells accumulate, he posited, the body itself begins to age and decline. The only cells that do not go into senescence, he added, are cancer cells.As a result of this cellular clock, he said, no amount of diet or exercise or genetic tweaking will push the human species past a life span of about 125 years.This finding, which the Nobel-winning virologist Macfarlane Burnet later called the Hayflick limit, ran counter to everything scientists believed about cells and aging — especially the thesis that cells themselves are immortal, and that aging is a result of external causes, like disease, diet and solar radiation.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      Fauci Speaks His Mind on Trump’s Rages and Their ‘Complicated’ Relationship

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      In a new book, Dr. Anthony S. Fauci recounts a career advising seven presidents. The chapter about Donald J. Trump is titled “He Loves Me, He Loves Me Not.”Three months into the coronavirus pandemic, Dr. Anthony S. Fauci was at home in northwest Washington when he answered his cellphone to President Donald J. Trump screaming at him in an expletive-laden rant. He had incurred the president’s wrath by remarking that the vaccines under development might not provide long-lasting immunity.That was the day, June 3, 2020, “that I first experienced the brunt of the president’s rage,” Dr. Fauci writes in his forthcoming autobiography.Dr. Fauci has long been circumspect in describing his feelings toward Mr. Trump. But in the book, “On Call: A Doctor’s Journey in Public Service,” he writes with candor about their relationship, which he describes as “complicated.”In a chapter entitled “He Loves Me, He Loves Me Not,” Dr. Fauci described how Mr. Trump repeatedly told him he “loved” him while at the same time excoriating him with tirades flecked with four-letter words.“The president was irate, saying that I could not keep doing this to him,” Dr. Fauci wrote. “He said he loved me, but the country was in trouble, and I was making it worse. He added that the stock market went up only 600 points in response to the positive Phase 1 vaccine news, and it should have gone up 1,000 points, and so I cost the country ‘one trillion dollars.’” (The president added an expletive.)“I have a pretty thick skin,” Dr. Fauci added, “but getting yelled at by the president of the United States, no matter how much he tells you that he loves you, is not fun.”We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      What to Know About New Covid Variants, ‘FLiRT’: Symptoms, Vaccines and More

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      Experts are closely watching KP.2, now the leading variant.For most of this year, the JN.1 variant of the coronavirus accounted for an overwhelming majority of Covid cases. But now, an offshoot variant called KP.2 is taking off. The variant, which made up just one percent of cases in the United States in mid-March, now makes up over a quarter.KP.2 belongs to a subset of Covid variants that scientists have cheekily nicknamed “FLiRT,” drawn from the letters in the names of their mutations. They are descendants of JN.1, and KP.2 is “very, very close” to JN.1, said Dr. David Ho, a virologist at Columbia University. But Dr. Ho has conducted early lab tests in cells that suggest that slight differences in KP.2’s spike protein might make it better at evading our immune defenses and slightly more infectious than JN.1.While cases currently don’t appear to be on the rise, researchers and physicians are closely watching whether the variant will drive a summer surge.“I don’t think anybody’s expecting things to change abruptly, necessarily,” said Dr. Marc Sala, co-director of the Northwestern Medicine Comprehensive Covid-19 Center in Chicago. But KP.2 will most likely “be our new norm,’” he said. Here’s what to know.The current spread of CovidExperts said it would take several weeks to see whether KP.2 might lead to a rise in Covid cases, and noted that we have only a limited understanding of how the virus is spreading. Since the public health emergency ended, there is less robust data available on cases, and doctors said fewer people were using Covid tests.But what we do know is reassuring: Despite the shift in variants, data from the C.D.C. suggests there are only “minimal” levels of the virus circulating in wastewater nationally, and emergency department visits and hospitalizations fell between early March and late April.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      Robert F. Kennedy Jr. Says Americans Are ‘Voting Out of Fear’

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      Robert F. Kennedy Jr. sought to make the case on Sunday that he can do something no third-party or independent candidate has come close to doing in modern U.S. history: win a presidential election. Although polls show him far behind, both major-party campaigns, those of President Biden and former President Donald J. Trump, view Mr. Kennedy as a potential spoiler.Speaking at a rally on Long Island outside New York City, Mr. Kennedy cited polls that he said his campaign had conducted, showing him winning in two scenarios: one in which he faced only Mr. Biden without Mr. Trump in the race, and one in which he faced Mr. Trump without Mr. Biden.The reason he is behind in a three-way race, he maintained, is that “so many Americans are voting out of fear.”“Their only strategy is to try to keep me off the ballot and then to make everybody terrified of Donald Trump,” he said of Democrats, “and on the other side, they do the same thing,” he added of Republicans. “When somebody is telling you to vote out of fear, they are trying to manipulate you into abandoning your values,” he said.Mr. Kennedy acknowledged to the crowd in Holbrook, N.Y., that Mr. Biden and Mr. Trump differed in numerous ways.“If you look at their personalities, their dispositions, their presentation, their ideology, their approach to life, their interactions with other people, there’s a huge, huge difference,” he said.But he argued that issues on which Mr. Biden and Mr. Trump held starkly different positions — like abortion, border security, guns and transgender rights — were “culture war issues” that “are used to divide us all.” He said that on the national debt and chronic disease — issues he called “existential for our country” — their positions weren’t materially different.In discussing the prevalence of chronic disease, Mr. Kennedy lamented the United States’ disproportionately high death rate from the coronavirus compared with the death rate experienced by other developed countries, a disparity attributable in part to the comparatively low uptake of vaccines that Mr. Kennedy has campaigned against.He suggested — in contradiction of scientific evidence of the safety and efficacy of Covid vaccines, and data showing higher death rates in states with lower vaccination rates — that the nation’s poor Covid performance was a mark against vaccines.“Whatever we’re doing, whatever we did, it was wrong,” Mr. Kennedy said, referring to vaccine mandates, lockdowns and other pandemic responses. More

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      Millions of Girls in Africa Will Miss HPV Shots After Merck Production Problem

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      The company has told countries that it can supply only 18.8 million of the 29.6 million doses it was contracted to deliver this year.Nearly 1.5 million teenage girls in some of the world’s poorest countries will miss the chance to be protected from cervical cancer because the drugmaker Merck has said it will not be able to deliver millions of promised doses of the HPV vaccine this year.Merck has notified Gavi, the international organization that helps low- and middle-income countries deliver lifesaving immunizations, and UNICEF, which procures the vaccines, that it will deliver only 18.8 million of the 29.6 million doses it was contracted to deliver in 2024, Gavi said.That means that more than 10 million girls will not receive their expected HPV shots this year — and 1.5 million of them most likely will never get them because they will be too old to qualify for the vaccine in subsequent years.Patrick Ryan, a spokesman for Merck, said the company “experienced a manufacturing disruption” that required it to hold and reinspect many doses by hand. He declined to give further details about the cause of the delay.“We are acting with urgency and rigor to deploy additional personnel and resources to resolve this matter as soon as possible,” he said.Mr. Ryan said that Merck would deliver the delayed doses in 2025. He also said the company would ship 30 million doses of the vaccine to Gavi-supported countries this year. However, about a third of these are doses that were supposed to have been sent in 2023, leaving Gavi with the 10.7 million dose shortfall.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      Brazil Police Recommend Criminal Charges Against Bolsonaro

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      The federal police accused the former president of falsifying his Covid-19 vaccination records. Brazil’s federal police recommended former President Jair Bolsonaro be criminally charged in a scheme to falsify his Covid-19 vaccine card, partly to travel to the United States during the pandemic, in the latest sign of criminal investigations closing in on the former president.Federal prosecutors will now decide whether to pursue the case. If they do, it would be the first time the former president has faced criminal charges.Brazilian police accused Mr. Bolsonaro of ordering a top deputy to obtain falsified Covid-19 vaccination records for himself and his daughter, 13, in late 2022, just before the former president traveled to Florida to stay for three months following his election loss. Brazilian police said they were awaiting an answer from the U.S. Justice Department on whether Mr. Bolsonaro used a fake vaccination card to enter the United States, which could bring different criminal charges. At the time, most international visitors to the U.S. were required to show proof of Covid-19 vaccination to enter the country.Mr. Bolsonaro has said he did not receive the Covid-19 vaccine, but he has denied accusations that he was involved in any plan to falsify his vaccination records. His lawyer said in a text message that he was still reviewing the accusations.Mr. Bolsonaro, if convicted of forging his vaccine card, could face prison time.The federal police’s indictment is the first time the various investigations into Mr. Bolsonaro have moved toward charges. Mr. Bolsonaro has been subject to questioning and searches as part of several inquiries, including into the selling of watches and jewels he received as presidential gifts from Saudi Arabia and accusations that he worked with top government officials to hatch a plan to try to hold onto power following his 2022 election loss. Brazil’s electoral court has already ruled Mr. Bolsonaro ineligible for public office until 2030 for spreading false information about Brazil’s voting systems on state television, forcing him to sit out the next presidential contest in 2026.During the pandemic, Mr. Bolsonaro was critical of the Covid-19 vaccine, notoriously joking that it would turn people into alligators and instead promoting unproven treatments, such as an antimalarial drug called hydroxychloroquine. His administration hesitated to secure vaccines when they were first being distributed, exacerbating the pandemic in Brazil, according to a Brazilian congressional investigation that recommended the former president be charged with “crimes against humanity,” among other charges, for his actions during the pandemic. The prosecutor at the time did not charge him. Nearly 600,000 people died in Brazil because of Covid-19, the second-highest national death count after the United States.In May 2023, the police searched Mr. Bolsonaro’s home, confiscated his cellphone and arrested one of his closest aides and two of his security guards as part of the investigation into the fake vaccination records.Flávia Milhorance More