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    Citing N.I.H. Cuts, a Top Science Journal Stops Accepting Submissions

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    With federal support, Environmental Health Perspectives has long published peer-reviewed studies without fees to readers or scientists.Environmental Health Perspectives, widely considered the premier environmental health journal, has announced that it would pause acceptance of new studies for publication, as federal cuts have left its future uncertain.For more than 50 years, the journal has received funding from the National Institutes of Health to review studies on the health effects of environmental toxins — from “forever chemicals” to air pollution — and publish the research free of charge.The editors made the decision to halt acceptance of studies because of a “lack of confidence” that contracts for critical expenses like copy-editing and editorial software would be renewed after their impending expiration dates, said Joel Kaufman, the journal’s top editor.He declined to comment on the publication’s future prospects. “If the journal is indeed lost, it is a huge loss,” said Jonathan Levy, chair of the department of environmental health at Boston University. “It’s reducing the ability for people to have good information that can be used to make good decisions.”The news comes weeks after a federal prosecutor in Washington sent letters to several scientific journals, including The New England Journal of Medicine, with questions that suggested that they were biased against certain views and influenced by external pressures.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      RFK Jr. Offers Qualified Support for Measles Vaccination

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      In an interview with CBS, the health secretary also suggested he wasn’t familiar with massive cuts to state funding for public health.In a rare sit-down interview with CBS News, Robert F. Kennedy Jr., the nation’s health secretary, recommended the measles vaccine and said he was “not familiar” with sweeping cuts to state and local public health programs.The conversation was taped shortly after his visit to West Texas, where he attended the funeral of an 8-year-old girl who died after contracting measles. A raging outbreak there has sickened more than 500 people and killed two young children.In clips of the discussion released Wednesday, Mr. Kennedy offered one of his strongest endorsements yet of the measles vaccine. “People should get the measles vaccine, but the government should not be mandating those,” he said.A few moments later, however, he raised safety concerns about the shot, as he has previously: “We don’t know the risks of many of these products because they’re not safety tested,” he said.For months, Mr. Kennedy has faced intense criticism for his handling of the West Texas outbreak from medical experts who believe that his failure to offer a full-throated endorsement of immunization has hampered efforts to contain the virus.Moreover, he has promoted unproven treatments for measles, like cod liver oil. Doctors in Texas believe its use is tied to signs of liver toxicity in some children arriving in local hospitals.Throughout the outbreak, Mr. Kennedy has often paired support for vaccines with discussions of safety concerns about the shots, along with “miraculous” alternative treatments.Over the weekend, he posted on social media that the measles, mumps and rubella vaccine was “the most effective way” to prevent the spread of measles — a statement met with relief from infectious disease experts and with fury from his vaccine-hesitant base.That night, he posted again, this time applauding “two extraordinary healers” who he claimed had effectively treated roughly 300 measles-stricken children with budesonide, a steroid, and clarithromycin, an antibiotic.Scientists say there are no cures for a measles infection, and that claiming otherwise undermines the importance of a vaccination.Later in the CBS interview, Mr. Kennedy was pressed on the administration’s recent move to halt more than $12 billion in federal grants to state programs that address infectious disease, mental health and childhood vaccinations, among other efforts.(A judge has temporarily blocked the cuts after a coalition of states sued the Trump administration.)Mr. Kennedy said he wasn’t familiar with the interruptions, then asserted that they were “mainly D.E.I. cuts,” referring to diversity, equity and inclusion programs that have been targeted by the Trump administration.Dr. Jonathan LaPook, CBS’s medical correspondent, asked about specific research cuts at universities, including a $750,000 grant to researchers at the University of Michigan to study adolescent diabetes.“I didn’t know that, and that’s something that we’ll look at,” Mr. Kennedy said. “There’s a number of studies that were cut that came to our attention and that did not deserve to be cut, and we reinstated them.” More

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      A Second Child Dies of Measles in Texas

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      It is the second confirmed measles death in the U.S. in a decade. If the outbreak continues at the current pace, the nation may lose its “elimination” status.The measles crisis in West Texas has claimed the life of another child, the second death in an outbreak that has burned through the region and infected dozens of residents in bordering states.The 8-year-old girl died early Thursday morning of “measles pulmonary failure” at a hospital in Lubbock, Texas, according to records obtained by The New York Times. It is the second confirmed measles death in a decade in the United States.The first was an unvaccinated child who died in West Texas in February. Another unvaccinated person died in New Mexico after testing positive for measles, though officials have not yet confirmed that measles was the cause of death.A Trump administration official said on Saturday night that the girl’s cause of death is “still being looked at.” Since late January, when the outbreak began, West Texas has reported 480 cases of measles and 56 hospitalizations. The outbreak has also spread to bordering states, sickening 54 people in New Mexico and 10 in Oklahoma.If the virus continues to spread at this pace, the country risks losing its measles elimination status, a hard-fought victory earned in 2000. Public health officials in West Texas have predicted the outbreak will continue for a year.Robert F. Kennedy, the nation’s health secretary, has faced intense criticism for his handling of the outbreak. A prominent vaccine skeptic, he has offered muted support for vaccination and has emphasized untested treatments for measles, like cod liver oil.According to doctors in Texas, Mr. Kennedy’s endorsement of alternative treatments has contributed to patients delaying critical care and ingesting toxic levels of vitamin A.Experts also fear that the Trump administration’s recent decisions to dismantle international public health safeguards and pull funding from local health departments have made large, multistate outbreaks more likely.Measles is one of the most contagious pathogens. The virus can linger in the air for up to two hours after an infected person has left the room and spreads when a sick person breathes, coughs or sneezes.Within a week or two of being exposed, those who are infected may develop a high fever, cough, runny nose and red, watery eyes. Within a few days, a telltale rash breaks out as flat, red spots on the face and then spreads down the neck and torso to the rest of the body.In most cases, these symptoms resolve in a few weeks. But in rare cases, the virus causes pneumonia, making it difficult for patients, but especially children, to get oxygen into their lungs.It may also cause brain swelling, which can leave lasting problems, like blindness, deafness and intellectual disabilities.For every 1,000 children who get measles, one or two will die, according to the Centers for Disease Control and Prevention. The virus also harms the body’s immune defenses, leaving it vulnerable to other pathogens.Christina Jewett More

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      Trump Administration Demands Additional Cuts at C.D.C.

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      In addition to reductions at agency personnel, federal regulators are demanding $2.9 billion in contract cancellations, The Times has learned.Alongside extensive reductions to the staff of the Centers for Disease Control and Prevention, the Trump administration has asked the agency to cut $2.9 billion of its spending on contracts, according to three federal officials with knowledge of the matter.The administration’s cost-cutting program, called the Department of Government Efficiency, asked the public health agency to sever roughly 35 percent of its spending on contracts about two weeks ago. The C.D.C. was told to comply by April 18, according to the officials.The cuts promise to further hamstring an agency already reeling from the loss of 2,400 employees, nearly one-fifth of its work force. On Tuesday, the administration fired C.D.C. scientists focused on environmental health and asthma, injuries, violence prevention, lead poisoning, smoking and climate change.Officials at the White House and the Department of Health and Human Services did not immediately respond to requests for comment.Abruptly cutting 35 percent of contracts would be tough for any organization or business, said Tom Inglesby, director of the Johns Hopkins Center for Health Security at the Bloomberg School of Public Health, who advised the Biden administration during Covid.“Sure, any manager can find small savings and improvements, but these kinds of demands are of the size and speed that break down organizations,” he said. “This is not the way to do good for the public or for the public’s health.”The C.D.C.’s largest contract, about $7 billion per year, goes to the Vaccines for Children Program, which purchases vaccines for parents who may not be able to afford them. That program is mandated by law and will not be affected by the cuts, according to one senior official who spoke on condition of anonymity.But other C.D.C. contracts include spending on computers and other technology, security guards, cleaning services and facilities management. The agency also hires people to build and maintain data systems and for specific research projects. Over the past several years, contracts have also supported activities related to Covid-19, one official said.Separately, H.H.S. last week abruptly discontinued C.D.C. grants of about $11.4 billion to states that were using the funds to track infectious diseases and to support mental health services, addiction treatment and other urgent health issues.At least some of the contracts D.O.G.E. is now asking the agency to discontinue may no longer be implemented because the people overseeing them have been fired. This is not the first time D.O.G.E. asked the agency to cut funding. It previously asked the C.D.C. to cut grants to Columbia University and University of Pennsylvania, saying those institutions had failed to take action against antisemitism on campus. “Funding grants and contracts are the mechanism by which we get things done,” said one C.D.C. scientist who asked to remain anonymous because of a fear of retaliation. “They are cutting off our arms and legs.” More

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      Shingles Vaccine Can Decrease Risk of Dementia, Study Finds

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      A growing body of research suggests that preventing the viral infection can help stave off cognitive decline.Getting vaccinated against shingles can reduce the risk of developing dementia, a large new study finds.The results provide some of the strongest evidence yet that some viral infections can have effects on brain function years later and that preventing them can help stave off cognitive decline.The study, published on Wednesday in the journal Nature, found that people who received the shingles vaccine were 20 percent less likely to develop dementia in the seven years afterward than those who were not vaccinated.“If you’re reducing the risk of dementia by 20 percent, that’s quite important in a public health context, given that we don’t really have much else at the moment that slows down the onset of dementia,” said Dr. Paul Harrison, a professor of psychiatry at Oxford. Dr. Harrison was not involved in the new study, but has done other research indicating that shingles vaccines lower dementia risk.Whether the protection can last beyond seven years can only be determined with further research. But with few currently effective treatments or preventions, Dr. Harrison said, shingles vaccines appear to have “some of the strongest potential protective effects against dementia that we know of that are potentially usable in practice.”Shingles cases stem from the virus that causes childhood chickenpox, varicella-zoster, which typically remains dormant in nerve cells for decades. As people age and their immune systems weaken, the virus can reactivate and cause shingles, with symptoms like burning, tingling, painful blisters and numbness. The nerve pain can become chronic and disabling.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      F.D.A. Expands Access to Clozapine, a Key Treatment for Schizophrenia

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      Federal regulators will no longer require patients to provide blood tests before receiving the drug from pharmacies.The Food and Drug Administration has taken a crucial step toward expanding access to the antipsychotic medication clozapine, the only drug approved for treatment-resistant schizophrenia, among the most devastating of mental illnesses.The agency announced on Monday that it was eliminating a requirement that patients submit blood tests before their prescriptions can be filled.Clozapine, which was approved in 1989, is regarded by many physicians as the most effective available treatment for schizophrenia, and research shows that the drug significantly reduces suicidal behavior. Clozapine is also associated with a rare side effect called neutropenia, a drop in white blood cell counts that, in its most severe form, can be life-threatening.In 2015, federal regulators imposed a regimen known as risk evaluation and mitigation strategies, or REMS, that required patients to submit to weekly, biweekly and monthly blood tests that had to be uploaded onto a database and verified by pharmacists.Physicians have long complained that, as a result, clozapine is grossly underutilized.Dr. Frederick C. Nucifora, director of the Adult Schizophrenia Clinic at the Johns Hopkins School of Medicine, said he believed that around 30 percent of patients with schizophrenia would benefit from clozapine — far more than the 4 percent who currently take it.“I have had many patients who were doing terribly, who struggled to function outside the hospital, and cycled through many medications,” he said. “If they go on clozapine, they really tend to not be hospitalized again. I’ve had people go on to finish college and work. It’s quite remarkable.”We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      Scientists Describe Rare Syndrome Following Covid Vaccinations

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      In a small study, patients with the syndrome were more likely to experience reactivation of Epstein-Barr virus and high levels of a coronavirus protein.The Covid-19 vaccines were powerfully protective, preventing millions of deaths. But in a small number of people, the shots may have led to a constellation of side effects that includes fatigue, exercise intolerance, brain fog, tinnitus and dizziness, together referred to as “post-vaccination syndrome,” according to a small new study.Some people with this syndrome appear to show distinct biological changes, the research found — among them differences in immune cells, reawakening of a dormant virus called Epstein-Barr, and the persistence of a coronavirus protein in their blood.The study was posted online Wednesday and has not yet been published in a scientific journal. “I want to emphasize that this is still a work in progress,” said Akiko Iwasaki, an immunologist at Yale University who led the work.“It’s not like this study determined what’s making people sick,” she said, “but it’s the first kind of glimpse at what may be going on within these people.”Independent experts noted that the findings were not conclusive on their own. Yet the results, from a scientific team known for rigorous work, suggest that post-vaccination syndrome deserves further scrutiny, they said.“One of the most important things is that we get some attention to really shine a light on this and try to understand exactly what it is,” said John Wherry, director of the Institute for Immunology at the University of Pennsylvania. (Dr. Wherry has previously collaborated with Dr. Iwasaki’s team, but did not participate in this work.)We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      An Invisible Medical Shortage: Oxygen

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      Oxygen is vital to many medical procedures. But a safe, affordable supply is severely lacking around the world, according to a new report.At the height of the Covid-19 pandemic, millions of people in poor nations died literally gasping for breath, even in hospitals. What they lacked was medical oxygen, which is in short supply in much of the world.On Monday, a panel of experts published a comprehensive report on the shortage. Each year, the report noted, more than 370 million people worldwide need oxygen as part of their medical care, but fewer than 1 in 3 receive it, jeopardizing the health and lives of those who do not. Access to safe and affordable medical oxygen is especially limited in low- and middle-income nations.“The need is very urgent,” said Dr. Hamish Graham, a pediatrician and a lead author of the report. “We know that there’s more epidemics coming, and there’ll be another pandemic, probably like Covid, within the next 15 to 20 years.”The report, published in The Lancet Global Health, comes just weeks after the Trump administration froze foreign aid programs, including some that could improve access to oxygen.Boosting the availability of medical oxygen would require an investment of about $6.8 billion, the report noted. “Within the current climate, that’s obviously going to become a bit more of a challenge,” said Carina King, an infectious disease epidemiologist at the Karolinska Institute and a lead author of the report.Still, she said, governments and funding organizations should prioritize medical oxygen because of its importance across health care. People of all ages may need oxygen for pneumonia and other respiratory conditions, for severe infections including malaria and sepsis, for surgeries and for chronic lung conditions.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      CDC Posts, Then Deletes, Data on Bird Flu Transmission Between Cats and People

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      The data, which appeared fleetingly online on Wednesday, confirmed transmission in two households. Scientists called on the agency to release the full report.Cats that became infected with bird flu might have spread the virus to humans in the same household and vice versa, according to data that briefly appeared online in a report from the Centers for Disease Control and Prevention but then abruptly vanished. The data appear to have been mistakenly posted but includes crucial information about the risks of bird flu to people and pets.In one household, an infected cat might have spread the virus to another cat and to a human adolescent, according to a copy of the data table obtained by The New York Times. The cat died four days after symptoms began. In a second household, an infected dairy farmworker appears to have been the first to show symptoms, and a cat then became ill two days later and died on the third day.The table was the lone mention of bird flu in a scientific report published on Wednesday that was otherwise devoted to air quality and the Los Angeles County wildfires. The table was not present in an embargoed copy of the paper shared with news media on Tuesday, and is not included in the versions currently available online. The table appeared briefly at around 1 p.m., when the paper was first posted, but it is unclear how or why the error might have occurred.The virus, called H5N1, is primarily adapted to birds, but it has been circulating in dairy cattle since early last year. H5N1 has also infected at least 67 Americans but does not yet have the ability to spread readily among people. Only one American, in Louisiana, has died of an H5N1 infection so far.The report was part of the C.D.C.’s prestigious Morbidity and Mortality Weekly Report, which, until two weeks ago, had regularly published every week since the first installment decades ago. But a communications ban on the agency had held the reports back, until the wildfire report was published on Wednesday.Experts said that the finding that cats might have passed the virus to people was not entirely unexpected. But they were alarmed that the finding had not yet been released to the public.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More